Vital-IT Computational Biology

Focus on the group's mission

The Vital-IT group, led by Mark Ibberson, acts as a key sustainable bioinformatics resource serving national and international projects and collaborations, with academic and industry partners. Thanks to its diverse expertise in computational biology, data management and software engineering, the team is able to find custom-made solutions to answer complex biological questions including biomedical & omics data. The value it delivers to its partners is a deep commitment to advancing science effectively and independently.

As both computational biologists and software developers, we understand data and how to manage them, as well as the underlying biological questions. Our focus is on finding innovative approaches to data analysis, such as overcoming constraints related to sensitive data, or interconnecting data through knowledge graphs.

Mark Ibberson

Director of SIB's Vital-IT Group

Knowledge management

Our knowledge management and data stewardship competencies enable us to get novel and faster insights into complex datasets. We organize, clean & control the quality of your datasets for subsequent analysis. In addition, we process, transform and align your datasets to existing standards and make them available as a database. We are specialized in handling different types of omics data (e.g. RNA-Seq, metabolomics, lipidomics, proteomics, transcriptomics, microbiomics) including sensitive data, for which we can provide bespoke solutions (e.g. federated analysis or secure dedicated servers for remote analysis). Our specialties include:

FAIR Data management
Data and literature curation
Knowledge representation

In practice:

Set up of a federated database for biomarker discovery in type 2 diabetes (T2D) as part of the IMI RHAPSODY consortium. In this database, 10 observational clinical cohorts with a combined total of 50K patients were standardized, harmonized and made available for statistical analysis. We developed data mining and statistical tools in an analysis package for researchers to use within the consortium. Read more and watch the video
Set up of a database composed of ~100 clinical trials as part of the IMI Hypo-RESOLVE consortium. The work has involved setting up ETL (extract, transform, load) pipeline for feeding trial data into a secure Oracle database and the creation of a virtual analysis environment accessible via remote desktop and secured by 2 factor authentication.
Set up of secure pipelines to process and analyse exome sequencing data in various cancers, in order to identify the factors responsible for resistance to immunotherapy, as part of the IMI IMMUcan project.

More about SIB’s role in European public-private partnerships

Data mining and analysis

We propose analysis pipelines adapted to each research context, including multi-omics models and results interpretation. Our specialties include:

Omics analysis
Integrative and network analysis
Machine learning

In practice:

Development of a method for interpreting gene expression data with metabolic models which has helped to identify key genes in obesity-related inflammation in adipose tissue (read the paper)
Integrative analysis of mouse and human lipidomics data which led to the discovery of novel lipid biomarker candidates for T2D (read the paper)
Transcript assembly and functional characterization of heart-specific lncRNAs in collaboration with the University of Lausanne Medical School (read the paper)
Transcriptomics data analysis from muscle biopsies in a human clinical trial investigating the effect of Urolithin A on muscle function (read the paper)

Bioinformatics tools

We develop tailored web applications and software tools to present, analyze, visualize and interpret data and results. We use various standards as appropriate to ensure interoperability and reusability (e.g. W3C standards such as RDF).

In practice:

Development, in collaboration with EMBO, of SourceData - a web-based platform for curating and annotating figures in scientific publications (read the paper).
Development, in collaboration with the SIB Clinical Bioinformatics Group and the Geneva University Hospitals (HUG), of Oncobench ® - a software platform to help cancer diagnosis (read the news)

Access our software stack

Software tools & web applications

Our approach

We strive to establish partnerships: even for one-off collaborations, we seek to deeply understand the data and the objectives of the project we work on. Our partners appreciate our reliability, commitment and team spirit.

Our track record spans biomedical research projects of different sizes - from punctual help to long-term European projects.

We are recognized for our flexibility and independence, allowing us to tailor efficient solutions and propose advisory services to each situation. For example, the collaboration can be customized to include our partner's own ontologies, provide support to validate internal approaches or integrate large and complex amounts of data of various types and origins.

We train both beginners and experts in bioinformatics methods, languages and best practices.

Our highly qualified team of 30 people has an average experience of over 10 years in the bioinformatics field.

Arnaud Dance, Justine Fernandes, Bénédicte Toussaint, Emmanuel Vaillant, Raphaël Boutry, Morgane Baron, Hélène Loiselle, Beverley Balkau, Guillaume Charpentier, Sylvia Franc, Mark Ibberson, Michel Marre, Marie Gernay, Marjorie Fadeur, Nicolas Paquot, Martine Vaxillaire, Mathilde Boissel, Souhila Amanzougarene, Mehdi Derhourhi, Amna Khamis, Philippe Froguel, Amélie Bonnefond Exploring the Role of Purinergic Receptor P2RY1 in Type 2 Diabetes Risk and Pathophysiology: Insights from Human Functional Genomics. Molecular metabolism (2023) doi: 10.1016/j.molmet.2023.101867
Caroline S Meier, Marco Pagni, Sophie Richard, Konrad Mühlethaler, João M G C F Almeida, Gilles Nevez, Melanie T Cushion, Enrique J Calderón, Philippe M Hauser Publisher Correction: Fungal antigenic variation using mosaicism and reassortment of subtelomeric genes' repertoires. Nature communications, 14 (2023) doi: 10.1038/s41467-023-43993-7
Judit Castillo-Armengol, Flavia Marzetta, Ana Rodriguez Sanchez-Archidona, Christian Fledelius, Mark Evans, Alison McNeilly, Rory J McCrimmon, Mark Ibberson, Bernard Thorens Disrupted hypothalamic transcriptomics and proteomics in a mouse model of type 2 diabetes exposed to recurrent hypoglycaemia. Diabetologia (2023) doi: 10.1007/s00125-023-06043-x
Caroline S Meier, Marco Pagni, Sophie Richard, Konrad Mühlethaler, João M G C F Almeida, Gilles Nevez, Melanie T Cushion, Enrique J Calderón, Philippe M Hauser Fungal antigenic variation using mosaicism and reassortment of subtelomeric genes' repertoires. Nature communications, 14 (2023) doi: 10.1038/s41467-023-42685-6
Oliver FitzGerald, Frank Behrens, Anne Barton, Heidi Bertheussen, Bruno Boutouyrie-Dumont, Laura Coates, Owen Davies, Maarten de Wit, Filippo Fagni, Carl S Goodyear, Robert Gurke, Lisa Hahnefeld, Christine Huppertz, Vassilios Ioannidis, Mark Ibberson, Arnon Katz, Maximilian Klippstein, Michaela Koehm, Shimon Korish, Sina Mackay, David A Martin, Denis O'Sullivan, Khadijah Patel, Stefan Rueping, Georg Schett, Klaus Scholich, Jochen M Schwenk, Stefan Siebert, David Simon, Arani Vivekanantham, Stephen R Pennington Application of clinical and molecular profiling data to improve patient outcomes in psoriatic arthritis. Therapeutic advances in musculoskeletal disease, 15 (2023) doi: 10.1177/1759720X231192315
Agnete T Lundgaard, Frédéric Burdet, Troels Siggaard, David Westergaard, Danai Vagiaki, Lisa Cantwell, Timo Röder, Dorte Vistisen, Thomas Sparsø, Giuseppe N Giordano, Mark Ibberson, Karina Banasik, Søren Brunak BALDR: A Web-based platform for informed comparison and prioritization of biomarker candidates for type 2 diabetes mellitus. PLoS computational biology, 19 (2023) doi: 10.1371/journal.pcbi.1011403
Sameer M Padhye, Mihir R Kulkarni, Marco Pagni, Nicolas Rabet New leptestherid clam shrimps (Pancrustacea: Branchiopoda: Spinicaudata: Leptestheriidae) from peninsular India. Zootaxa, 5264 (2023) doi: 10.11646/zootaxa.5264.2.3
Danielle Welter, Nick Juty, Philippe Rocca-Serra, Fuqi Xu, David Henderson, Wei Gu, Jolanda Strubel, Robert T Giessmann, Ibrahim Emam, Yojana Gadiya, Tooba Abbassi-Daloii, Ebtisam Alharbi, Alasdair J G Gray, Melanie Courtot, Philip Gribbon, Vassilios Ioannidis, Dorothy S Reilly, Nick Lynch, Jan-Willem Boiten, Venkata Satagopam, Carole Goble, Susanna-Assunta Sansone, Tony Burdett FAIR in action - a flexible framework to guide FAIRification. Scientific data, 10 (2023) doi: 10.1038/s41597-023-02167-2
Philippe Rocca-Serra, Wei Gu, Vassilios Ioannidis, Tooba Abbassi-Daloii, Salvador Capella-Gutierrez, Ishwar Chandramouliswaran, Andrea Splendiani, Tony Burdett, Robert T Giessmann, David Henderson, Dominique Batista, Ibrahim Emam, Yojana Gadiya, Lucas Giovanni, Egon Willighagen, Chris Evelo, Alasdair J G Gray, Philip Gribbon, Nick Juty, Danielle Welter, Karsten Quast, Paul Peeters, Tom Plasterer, Colin Wood, Eelke van der Horst, Dorothy Reilly, Herman van Vlijmen, Serena Scollen, Allyson Lister, Milo Thurston, Ramon Granell, , Susanna-Assunta Sansone The FAIR Cookbook - the essential resource for and by FAIR doers. Scientific data, 10 (2023) doi: 10.1038/s41597-023-02166-3
Roderick C Slieker, Louise A Donnelly, Elina Akalestou, Livia Lopez-Noriega, Rana Melhem, Ayşim Güneş, Frederic Abou Azar, Alexander Efanov, Eleni Georgiadou, Hermine Muniangi-Muhitu, Mahsa Sheikh, Giuseppe N Giordano, Mikael Åkerlund, Emma Ahlqvist, Ashfaq Ali, Karina Banasik, Søren Brunak, Marko Barovic, Gerard A Bouland, Frédéric Burdet, Mickaël Canouil, Iulian Dragan, Petra J M Elders, Celine Fernandez, Andreas Festa, Hugo Fitipaldi, Phillippe Froguel, Valborg Gudmundsdottir, Vilmundur Gudnason, Mathias J Gerl, Amber A van der Heijden, Lori L Jennings, Michael K Hansen, Min Kim, Isabelle Leclerc, Christian Klose, Dmitry Kuznetsov, Dina Mansour Aly, Florence Mehl, Diana Marek, Olle Melander, Anne Niknejad, Filip Ottosson, Imre Pavo, Kevin Duffin, Samreen K Syed, Janice L Shaw, Over Cabrera, Timothy J Pullen, Kai Simons, Michele Solimena, Tommi Suvitaival, Asger Wretlind, Peter Rossing, Valeriya Lyssenko, Cristina Legido Quigley, Leif Groop, Bernard Thorens, Paul W Franks, Gareth E Lim, Jennifer Estall, Mark Ibberson, Joline W J Beulens, Leen M 't Hart, Ewan R Pearson, Guy A Rutter Identification of biomarkers for glycaemic deterioration in type 2 diabetes. Nature communications, 14 (2023) doi: 10.1038/s41467-023-38148-7
Andrea Corona Ramirez, Danaé Bregnard, Thomas Junier, Guillaume Cailleau, Cristina Dorador, Saskia Bindschedler, Pilar Junier Assessment of fungal spores and spore-like diversity in environmental samples by targeted lysis. BMC microbiology, 23 (2023) doi: 10.1186/s12866-023-02809-w
Yohan Bignon, Leonore Wigger, Camille Ansermet, Benjamin D Weger, Sylviane Lagarrigue, Gabriel Centeno, Fanny Durussel, Lou Götz, Mark Ibberson, Sylvain Pradervand, Manfredo Quadroni, Meltem Weger, Francesca Amati, Frédéric Gachon, Dmitri Firsov Multiomics reveals multilevel control of renal and systemic metabolism by the renal tubular circadian clock. The Journal of clinical investigation (2023) doi: 10.1172/JCI167133
Karina Barreiro, Abigail C Lay, German Leparc, Van Du T Tran, Marcel Rosler, Lusyan Dayalan, Frederic Burdet, Mark Ibberson, Richard J M Coward, Tobias B Huber, Bernhard K Krämer, Denis Delic, Harry Holthofer An in vitro approach to understand contribution of kidney cells to human urinary extracellular vesicles. Journal of extracellular vesicles, 12 (2023) doi: 10.1002/jev2.12304
Samuel Neuenschwander, Diana I Cruz Dávalos, Lucas Anchieri, Bárbara Sousa da Mota, Davide Bozzi, Simone Rubinacci, Olivier Delaneau, Simon Rasmussen, Anna-Sapfo Malaspinas Mapache: a flexible pipeline to map ancient DNA. Bioinformatics (Oxford, England) (2023) doi: 10.1093/bioinformatics/btad028

Ewa Izabela Podobas, Danuta Gutowska-Owsiak, Sébastien Moretti, Jarosław Poznański, Mariusz Kulińczak, Marcin Grynberg, Aleksandra Gruca, Arkadiusz Bonna, Dawid Płonka, Tomasz Frączyk, Graham Ogg, Wojciech Bal Corrigendum: Ni-assisted hydrolysis may affect the human proteome; filaggrin degradation as an example of possible consequences. Frontiers in molecular biosciences, 9 (2022) doi: 10.3389/fmolb.2022.1101224
Mathilda Fatton, Sevasti Filippidou, Thomas Junier, Guillaume Cailleau, Matthieu Berge, Daniel Poppleton, Thorsten B Blum, Marek Kaminek, Adolfo Odriozola, Jochen Blom, Shannon L Johnson, Jan Pieter Abrahams, Patrick S Chain, Simonetta Gribaldo, Elitza I Tocheva, Benoît Zuber, Patrick H Viollier, Pilar Junier Cryptosporulation in Kurthia spp. forces a rethinking of asporogenesis in Firmicutes. Environmental microbiology, 24 (2022) doi: 10.1111/1462-2920.16145
Alysha S Taylor, Dinis Barros, Nastassia Gobet, Thierry Schuepbach, Branduff McAllister, Lorene Aeschbach, Emma L Randall, Evgeniya Trofimenko, Eleanor R Heuchan, Paula Barszcz, Marc Ciosi, Joanne Morgan, Nathaniel J Hafford-Tear, Alice E Davidson, Thomas H Massey, Darren G Monckton, Lesley Jones, Registry Investigators Of The European Huntington's Disease Network, Ioannis Xenarios, Vincent Dion Repeat Detector: versatile sizing of expanded tandem repeats and identification of interrupted alleles from targeted DNA sequencing. NAR genomics and bioinformatics, 4 (2022) doi: 10.1093/nargab/lqac089
Jonviea D Chamberlain, Sébastien Nusslé, Laurence Chapatte, Cassandre Kinnaer, Dusan Petrovic, Sylvain Pradervand, Murielle Bochud, Sarah E Harris, Janie Corley, Simon R Cox, Semira Gonseth Nusslé Blood DNA methylation signatures of lifestyle exposures: tobacco and alcohol consumption. Clinical epigenetics, 14 (2022) doi: 10.1186/s13148-022-01376-7
Dylan Lawless, Christopher G McKennan, Suman R Das, Thomas Junier, Zhi Ming Xu, Larry J Anderson, Tebeb Gebretsadik, Meghan H Shilts, Emma Larkin, Christian Rosas-Salazar, James D Chappell, Jacques Fellay, Tina V Hartert Viral genetic determinants of prolonged respiratory syncytial virus infection among infants in a healthy term birth cohort. The Journal of infectious diseases (2022) doi: 10.1093/infdis/jiac442
Robert Gurke, Annika Bendes, John Bowes, Michaela Koehm, Richard M Twyman, Anne Barton, Dirk Elewaut, Carl Goodyear, Lisa Hahnefeld, Rainer Hillenbrand, Ewan Hunter, Mark Ibberson, Vassilios Ioannidis, Sabine Kugler, Rik J Lories, Eduard Resch, Stefan Rüping, Klaus Scholich, Jochen M Schwenk, James C Waddington, Phil Whitfield, Gerd Geisslinger, Oliver FitzGerald, Frank Behrens, Stephen R Pennington, Omics and Multi-Omics Analysis for the Early Identification and Improved Outcome of Patients with Psoriatic Arthritis. Biomedicines, 10 (2022) doi: 10.3390/biomedicines10102387
Nastassia Gobet, Maxime Jan, Paul Franken, Ioannis Xenarios Towards mouse genetic-specific RNA-sequencing read mapping. PLoS computational biology, 18 (2022) doi: 10.1371/journal.pcbi.1010552
Anna L Gloyn, Mark Ibberson, Piero Marchetti, Alvin C Powers, Patrik Rorsman, Maike Sander, Michele Solimena Every islet matters: improving the impact of human islet research. Nature metabolism (2022) doi: 10.1038/s42255-022-00607-8
Olof Asplund, Petter Storm, Vikash Chandra, Gad Hatem, Emilia Ottosson-Laakso, Dina Mansour-Aly, Ulrika Krus, Hazem Ibrahim, Emma Ahlqvist, Tiinamaija Tuomi, Erik Renström, Olle Korsgren, Nils Wierup, Mark Ibberson, Michele Solimena, Piero Marchetti, Claes Wollheim, Isabella Artner, Hindrik Mulder, Ola Hansson, Timo Otonkoski, Leif Groop, Rashmi B Prasad Islet Gene View-a tool to facilitate islet research. Life science alliance, 5 (2022) doi: 10.26508/lsa.202201376
Aurélie Le Lay, Erwann Philippe, Fanny Roth, Ana Rodriguez Sanchez-Archidona, Florence Mehl, Jessica Denom, Rashmi Prasad, Olof Asplund, Ola Hansson, Mark Ibberson, Fabrizio Andreelli, Lyse Santoro, Paul Amouyal, Gilles Amouyal, Christian Brechot, Laure Jamot, Céline Cruciani-Guglielmacci, Christophe Magnan Regenerating islet-derived protein 3α: A promising therapy for diabetes. Preliminary data in rodents and in humans. Heliyon, 8 (2022) doi: 10.1016/j.heliyon.2022.e09944
Sanne Schrevens, Eric Durandau, Van Du T Tran, Dominique Sanglard Using transcriptomics and RNA enrichment to identify genes involved in virulence of . Virulence (2022) doi: 10.1080/21505594.2022.2095716
Eleni Georgiadou, Charanya Muralidharan, Michelle Martinez, Pauline Chabosseau, Elina Akalestou, Alejandra Tomas, Fiona Yong Su Wern, Theodoros Stylianides, Asger Wretlind, Cristina Legido-Quigley, Ben Jones, Livia Lopez Noriega, Yanwen Xu, Guoqiang Gu, Nour Alsabeeh, Céline Cruciani-Guglielmacci, Christophe Magnan, Mark Ibberson, Isabelle Leclerc, Yusuf Ali, Scott A Soleimanpour, Amelia K Linnemann, Tristan A Rodriguez, Guy A Rutter Mitofusins Mfn1 and Mfn2 are Required to Preserve Glucose- But Not Incretin-Stimulated Beta Cell Connectivity and Insulin Secretion. Diabetes (2022) doi: 10.2337/db21-0800
Christina Lemberg, Kontxi Martinez de San Vicente, Ricardo Fróis-Martins, Simon Altmeier, Van Du T Tran, Sarah Mertens, Sara Amorim-Vaz, Laxmi Shanker Rai, Christophe d'Enfert, Marco Pagni, Dominique Sanglard, Salomé LeibundGut-Landmann Candida albicans commensalism in the oral mucosa is favoured by limited virulence and metabolic adaptation. PLoS pathogens, 18 (2022) doi: 10.1371/journal.ppat.1010012
Ewa Izabela Podobas, Danuta Gutowska-Owsiak, Sébastien Moretti, Jarosław Poznański, Mariusz Kulińczak, Marcin Grynberg, Aleksandra Gruca, Arkadiusz Bonna, Dawid Płonka, Graham Ogg, Wojciech Bal Ni-Assisted Hydrolysis May Affect the Human Proteome; Filaggrin Degradation as an Example of Possible Consequences. Frontiers in molecular biosciences, 9 (2022) doi: 10.3389/fmolb.2022.828674
Yami Ommar Arizmendi Cárdenas, Samuel Neuenschwander, Anna-Sapfo Malaspinas Benchmarking metagenomics classifiers on ancient viral DNA: a simulation study. PeerJ, 10 (2022) doi: 10.7717/peerj.12784
Ewa Izabela Podobas, Danuta Gutowska-Owsiak, Sébastien Moretti, Jarosław Poznański, Mariusz Kulińczak, Marcin Grynberg, Aleksandra Gruca, Arkadiusz Bonna, Dawid Płonka, Graham Ogg and Wojciech Bal Ni2+-Assisted Hydrolysis May Affect the Human Proteome; Filaggrin Degradation Ex Vivo as an Example of Possible Consequences Frontiers in Molecular Biosciences (2022) url: https://www.frontiersin.org/articles/10.3389/fmolb.2022.828674/full
Aline Adler, Simon Poirier, Marco Pagni, Julien Maillard, Christof Holliger Disentangle genus microdiversity within a complex microbial community by using a multi-distance long-read binning method: example of Candidatus Accumulibacter. Environmental microbiology (2022) doi: 10.1111/1462-2920.15947

Ana Rodríguez Sánchez-Archidona, Céline Cruciani-Guglielmacci, Clara Roujeau, Leonore Wigger, Justine Lallement, Jessica Denom, Marko Barovic, Nadim Kassis, Florence Mehl, Jurgen Weitz, Marius Distler, Christian Klose, Kai Simons, Mark Ibberson, Michele Solimena, Christophe Magnan, Bernard Thorens Plasma triacylglycerols are biomarkers of ß-cell function in mice and humans. Molecular metabolism (2021) doi: 10.1016/j.molmet.2021.101355
Roderick C Slieker, Louise A Donnelly, Hugo Fitipaldi, Gerard A Bouland, Giuseppe N Giordano, Mikael Åkerlund, Mathias J Gerl, Emma Ahlqvist, Ashfaq Ali, Iulian Dragan, Petra Elders, Andreas Festa, Michael K Hansen, Amber A van der Heijden, Dina Mansour Aly, Min Kim, Dmitry Kuznetsov, Florence Mehl, Christian Klose, Kai Simons, Imre Pavo, Timothy J Pullen, Tommi Suvitaival, Asger Wretlind, Peter Rossing, Valeriya Lyssenko, Cristina Legido Quigley, Leif Groop, Bernard Thorens, Paul W Franks, Mark Ibberson, Guy A Rutter, Joline Wj Beulens, Leen M 't Hart, Ewan R Pearson Distinct Molecular Signatures of Clinical Clusters in People with Type 2 Diabetes: an IMIRHAPSODY Study. Diabetes (2021) doi: 10.2337/db20-1281
Kaan Mika, Steeve Cruchet, Phing Chian Chai, Lucia L Prieto-Godino, Thomas O Auer, Sylvain Pradervand, Richard Benton Olfactory receptor-dependent receptor repression in . Science advances, 7 (2021) doi: 10.1126/sciadv.abe3745
Leonore Wigger, Marko Barovic, Andreas-David Brunner, Flavia Marzetta, Eyke Schöniger, Florence Mehl, Nicole Kipke, Daniela Friedland, Frederic Burdet, Camille Kessler, Mathias Lesche, Bernard Thorens, Ezio Bonifacio, Cristina Legido-Quigley, Pierre Barbier Saint Hilaire, Philippe Delerive, Andreas Dahl, Christian Klose, Mathias J Gerl, Kai Simons, Daniela Aust, Jürgen Weitz, Marius Distler, Anke M Schulte, Matthias Mann, Mark Ibberson, Michele Solimena Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes. Nature metabolism (2021) doi: 10.1038/s42255-021-00420-9
Roderick C Slieker, Louise A Donnelly, Hugo Fitipaldi, Gerard A Bouland, Giuseppe N Giordano, Mikael Åkerlund, Mathias J Gerl, Emma Ahlqvist, Ashfaq Ali, Iulian Dragan, Andreas Festa, Michael K Hansen, Dina Mansour Aly, Min Kim, Dmitry Kuznetsov, Florence Mehl, Christian Klose, Kai Simons, Imre Pavo, Timothy J Pullen, Tommi Suvitaival, Asger Wretlind, Peter Rossing, Valeriya Lyssenko, Cristina Legido-Quigley, Leif Groop, Bernard Thorens, Paul W Franks, Mark Ibberson, Guy A Rutter, Joline W J Beulens, Leen M 't Hart, Ewan R Pearson Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study. Diabetologia (2021) doi: 10.1007/s00125-021-05490-8
Emanuele Bosi, Lorella Marselli, Carmela De Luca, Mara Suleiman, Marta Tesi, Mark Ibberson, Decio L Eizirik, Miriam Cnop, Piero Marchetti Correction to 'Integration of single-cell datasets reveals novel transcriptomic signatures of β-cells in human type 2 diabetes'. NAR genomics and bioinformatics, 3 (2021) doi: 10.1093/nargab/lqab053
Petra Baumgaertner, Martial Sankar, Fernanda Herrera, Fabrizio Benedetti, David Barras, Anne-Christine Thierry, Denarda Dangaj, Lana E Kandalaft, George Coukos, Ioannis Xenarios, Nicolas Guex, Alexandre Harari Unsupervised Analysis of Flow Cytometry Data in a Clinical Setting Captures Cell Diversity and Allows Population Discovery. Frontiers in immunology, 12 (2021) doi: 10.3389/fimmu.2021.633910
Florian Clemente, Martina Unterländer, Olga Dolgova, Carlos Eduardo G Amorim, Francisco Coroado-Santos, Samuel Neuenschwander, Elissavet Ganiatsou, Diana I Cruz Dávalos, Lucas Anchieri, Frédéric Michaud, Laura Winkelbach, Jens Blöcher, Yami Ommar Arizmendi Cárdenas, Bárbara Sousa da Mota, Eleni Kalliga, Angelos Souleles, Ioannis Kontopoulos, Georgia Karamitrou-Mentessidi, Olga Philaniotou, Adamantios Sampson, Dimitra Theodorou, Metaxia Tsipopoulou, Ioannis Akamatis, Paul Halstead, Kostas Kotsakis, Dushka Urem-Kotsou, Diamantis Panagiotopoulos, Christina Ziota, Sevasti Triantaphyllou, Olivier Delaneau, Jeffrey D Jensen, J Víctor Moreno-Mayar, Joachim Burger, Vitor C Sousa, Oscar Lao, Anna-Sapfo Malaspinas, Christina Papageorgopoulou The genomic history of the Aegean palatial civilizations. Cell (2021) doi: 10.1016/j.cell.2021.03.039
Heidi K Mod, Aline Buri, Erika Yashiro, Nicolas Guex, Lucie Malard, Eric Pinto-Figueroa, Marco Pagni, Hélène Niculita-Hirzel, Jan Roelof van der Meer, Antoine Guisan Predicting spatial patterns of soil bacteria under current and future environmental conditions. The ISME journal (2021) doi: 10.1038/s41396-021-00947-5
Robertas Ursache, Cristovāo De Jesus Vieira Teixeira, Valérie Dénervaud Tendon, Kay Gully, Damien De Bellis, Emanuel Schmid-Siegert, Tonni Grube Andersen, Vinay Shekhar, Sandra Calderon, Sylvain Pradervand, Christiane Nawrath, Niko Geldner, Joop E M Vermeer GDSL-domain proteins have key roles in suberin polymerization and degradation. Nature plants (2021) doi: 10.1038/s41477-021-00862-9
Anjali Kaushal, Giriram Mohana, Julien Dorier, Isa Özdemir, Arina Omer, Pascal Cousin, Anastasiia Semenova, Michael Taschner, Oleksandr Dergai, Flavia Marzetta, Christian Iseli, Yossi Eliaz, David Weisz, Muhammad Saad Shamim, Nicolas Guex, Erez Lieberman Aiden, Maria Cristina Gambetta CTCF loss has limited effects on global genome architecture in Drosophila despite critical regulatory functions. Nature communications, 12 (2021) doi: 10.1038/s41467-021-21366-2
Ming Hu, Inês Cebola, Gaelle Carrat, Shuying Jiang, Sameena Nawaz, Amna Khamis, Mickaël Canouil, Philippe Froguel, Anke Schulte, Michele Solimena, Mark Ibberson, Piero Marchetti, Fabian L Cardenas-Diaz, Paul J Gadue, Benoit Hastoy, Leonardo Alemeida-Souza, Harvey McMahon, Guy A Rutter Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion. Cell reports, 34 (2021) doi: 10.1016/j.celrep.2021.108703
S Neda Mousavy Gharavy, Bryn M Owen, Steven J Millership, Pauline Chabosseau, Grazia Pizza, Aida Martinez-Sanchez, Emirhan Tasoez, Eleni Georgiadou, Ming Hu, Nicholas H F Fine, David A Jacobson, Matthew T Dickerson, Olof Idevall-Hagren, Alex Montoya, Holger Kramer, Zenobia Mehta, Dominic J Withers, Nikolay Ninov, Paul J Gadue, Fabian L Cardenas-Diaz, Céline Cruciani-Guglielmacci, Christophe Magnan, Mark Ibberson, Isabelle Leclerc, Marianne Voz, Guy A Rutter Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis. Diabetologia (2021) doi: 10.1007/s00125-020-05350-x
Pilar Junier, Guillaume Cailleau, Ilona Palmieri, Celine Valloton, Olivia C Trautschold, Thomas Junier, Christophe Paul, Danae Bregnard, Fabio Palmieri, Aislinn Estoppey, Matteo Buffi, Andrea Lohberger, Aaron Robinson, Julia M Kelliher, Karen Davenport, Geoffrey L House, Demosthenes Morales, La Verne Gallegos-Graves, Armand E K Dichosa, Simone Lupini, Hang N Nguyen, Jamey D Young, Debora F Rodrigues, A Nicholas G Parra-Vasquez, Saskia Bindschedler, Patrick S G Chain Democratization of fungal highway columns as a tool to investigate bacteria associated with soil fungi. FEMS microbiology ecology (2021) doi: 10.1093/femsec/fiab003

Cristina Bosmani, Florence Leuba, Nabil Hanna, Frauke Bach, Frédéric Burdet, Marco Pagni, Monica Hagedorn, Thierry Soldati Vacuolins and myosin VII are required for phagocytic uptake and phagosomal membrane recycling in Dictyostelium discoideum. Journal of cell science (2020) doi: 10.1242/jcs.242974
Emanuele Bosi, Lorella Marselli, Carmela De Luca, Mara Suleiman, Marta Tesi, Mark Ibberson, Decio L Eizirik, Miriam Cnop, Piero Marchetti Integration of single-cell datasets reveals novel transcriptomic signatures of β-cells in human type 2 diabetes. NAR genomics and bioinformatics, 2 (2020) doi: 10.1093/nargab/lqaa097
Kathryn J Burton-Pimentel, Grégory Pimentel, Maria Hughes, Charlotte Cjr Michielsen, Attia Fatima, Nathalie Vionnet, Lydia A Afman, Helen M Roche, Lorraine Brennan, Mark Ibberson, Guy Vergères Discriminating dietary responses by combining transcriptomics and metabolomics data in nutrition intervention studies. Molecular nutrition & food research (2020) doi: 10.1002/mnfr.202000647
Lorella Marselli, Anthony Piron, Mara Suleiman, Maikel L Colli, Xiaoyan Yi, Amna Khamis, Gaelle R Carrat, Guy A Rutter, Marco Bugliani, Laura Giusti, Maurizio Ronci, Mark Ibberson, Jean-Valery Turatsinze, Ugo Boggi, Paolo De Simone, Vincenzo De Tata, Miguel Lopes, Daniela Nasteska, Carmela De Luca, Marta Tesi, Emanuele Bosi, Pratibha Singh, Daniela Campani, Anke M Schulte, Michele Solimena, Peter Hecht, Brian Rady, Ivona Bakaj, Alessandro Pocai, Lisa Norquay, Bernard Thorens, Mickaël Canouil, Philippe Froguel, Decio L Eizirik, Miriam Cnop, Piero Marchetti Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes. Cell reports, 33 (2020) doi: 10.1016/j.celrep.2020.108466
Emma Ricart, Maude Pupin, Markus Müller, Frédérique Lisacek Automatic Annotation and Dereplication of Tandem Mass Spectra of Peptidic Natural Products. Analytical chemistry (2020) doi: 10.1021/acs.analchem.0c03208
F Zanatta, R Engler, F Collart, O Broennimann, R G Mateo, B Papp, J Muñoz, D Baurain, A Guisan, A Vanderpoorten Bryophytes are predicted to lag behind future climate change despite their high dispersal capacities. Nature communications, 11 (2020) doi: 10.1038/s41467-020-19410-8
Sébastien Moretti, Van Du T Tran, Florence Mehl, Mark Ibberson, Marco Pagni MetaNetX/MNXref: unified namespace for metabolites and biochemical reactions in the context of metabolic models. Nucleic acids research (2020) doi: 10.1093/nar/gkaa992
Anne Gleizes, Florian Laubscher, Nicolas Guex, Christian Iseli, Thomas Junier, Samuel Cordey, Jacques Fellay, Ioannis Xenarios, Laurent Kaiser, Philippe Le Mercier Virosaurus A Reference to Explore and Capture Virus Genetic Diversity. Viruses, 12 (2020) doi: 10.3390/v12111248
Fabio Marino, Aikaterini Semilietof, Justine Michaux, Hui-Song Pak, George Coukos, Markus Müller, Michal Bassani-Sternberg Biogenesis of HLA Ligand Presentation in Immune Cells Upon Activation Reveals Changes in Peptide Length Preference. Frontiers in immunology, 11 (2020) doi: 10.3389/fimmu.2020.01981
Dionysios V Chartoumpekis, Panos G Ziros, Ilias Georgakopoulos-Soares, Adam A T Smith, Ana Claudia Marques, Mark Ibberson, Peter A Kopp, Ioannis Habeos, Ioannis P Trougakos, Nicholas K H Khoo, Gerasimos P Sykiotis The Transcriptomic Response of the Murine Thyroid Gland to Iodide Overload and the Role of the Nrf2 Antioxidant System. Antioxidants (Basel, Switzerland), 9 (2020) doi: 10.3390/antiox9090884
Rita Ahmed, Isaac Crespo, Sandra Tuyaerts, Amel Bekkar, Michele Graciotti, Ioannis Xenarios, Lana E Kandalaft Predicting combinations of immunomodulators to enhance dendritic cell-based vaccination based on a hybrid experimental and computational platform. Computational and structural biotechnology journal, 18 (2020) doi: 10.1016/j.csbj.2020.08.001
Gustavo A Ruiz Buendía, Marion Leleu, Flavia Marzetta, Ludovica Vanzan, Jennifer Y Tan, Victor Ythier, Emma L Randall, Ana C Marques, Tuncay Baubec, Rabih Murr, Ioannis Xenarios, Vincent Dion Three-dimensional chromatin interactions remain stable upon CAG/CTG repeat expansion. Science advances, 6 (2020) doi: 10.1126/sciadv.aaz4012
Heidi K Mod, Daniel Scherrer, Valeria Di Cola, Olivier Broennimann, Quentin Blandenier, Frank T Breiner, Aline Buri, Jérôme Goudet, Nicolas Guex, Enrique Lara, Edward A D Mitchell, Hélène Niculita-Hirzel, Marco Pagni, Loïc Pellissier, Eric Pinto-Figueroa, Ian R Sanders, Benedikt R Schmidt, Christophe V W Seppey, David Singer, Sylvain Ursenbacher, Erika Yashiro, Jan R van, der Meer, Antoine Guisan Greater topoclimatic control of above- Versus belowground communities. Global change biology (2020) doi: 10.1111/gcb.15330
Gustavo A Ruiz Buendía, Marion Leleu, Flavia Marzetta, Ludovica Vanzan, Jennifer Y Tan, Victor Ythier, Emma L Randall, Ana C Marques, Tuncay Baubec, Rabih Murr, Ioannis Xenarios, Vincent Dion Three-dimensional chromatin interactions remain stable upon CAG/CTG repeat expansion. Science advances, 6 (2020) doi: 10.1126/sciadv.aaz4012
Vasundra Touré, Steven Vercruysse, Marcio Luis Acencio, Ruth C Lovering, Sandra Orchard, Glyn Bradley, Cristina Casals-Casas, Claudine Chaouiya, Noemi Del-Toro, Åsmund Flobak, Pascale Gaudet, Henning Hermjakob, Charles Tapley Hoyt, Luana Licata, Astrid Lægreid, Christopher J Mungall, Anne Niknejad, Simona Panni, Livia Perfetto, Pablo Porras, Dexter Pratt, Julio Saez-Rodriguez, Denis Thieffry, Paul D Thomas, Dénes Türei, Martin Kuiper The Minimum Information about a Molecular Interaction Causal Statement (MI2CAST). Bioinformatics (Oxford, England) (2020) doi: 10.1093/bioinformatics/btaa622
I Castanon, J T Hannich, L Abrami, F Huber, M Dubois, M Müller, F G van der Goot, M Gonzalez-Gaitan Wnt-controlled sphingolipids modulate Anthrax Toxin Receptor palmitoylation to regulate oriented mitosis in zebrafish. Nature communications, 11 (2020) doi: 10.1038/s41467-020-17196-3
Emanuel Schmid-Siegert, Sophie Richard, Amanda Luraschi, Konrad Mühlethaler, Marco Pagni, Philippe M Hauser Expression pattern of the Pneumocystis jirovecii major surface glycoprotein superfamily in patients with pneumonia. The Journal of infectious diseases (2020) doi: 10.1093/infdis/jiaa342
Cristina Bosmani, Florence Leuba, Nabil Hanna, Frauke Bach, Frédéric Burdet, Marco Pagni, Monica Hagedorn, Thierry Soldati Vacuolins and myosin VII are required for phagocytic uptake and phagosomal membrane recycling in . Journal of cell science (2020) doi: 10.1242/jcs.242974
Jérémy Gauthier, Mila Pajkovic, Samuel Neuenschwander, Lauri Kaila, Sarah Schmid, Ludovic Orlando, Nadir Alvarez Museomics identifies genetic erosion in two butterfly species across the 20th century in Finland. Molecular ecology resources (2020) doi: 10.1111/1755-0998.13167
Dassine Berdous, Xavier Berney, Ana Rodriguez Sanchez-Archidona, Maxime Jan, Clara Roujeau, Isabel Lopez Mejia, Randall Mynatt, Bernard Thorens A Genetic Screen Identifies Crat As A Regulator Of Pancreatic Beta-Cell Insulin Secretion. Molecular metabolism (2020) doi: 10.1016/j.molmet.2020.100993
Christopher Dumayne, David Tarussio, Ana Rodriguez Sanchez-Archidona, Alexandre Picard, Davide Basco, Xavier Pascal Berney, Mark Ibberson, Bernard Thorens Klf6 protects β-cells against insulin resistance-induced dedifferentiation. Molecular metabolism, 35 (2020) doi: 10.1016/j.molmet.2020.02.001
Otmane Lamrabet, Astrid Melotti, Frédéric Burdet, Nabil Hanna, Jackie Perrin, Jahn Nitschke, Marco Pagni, Hubert Hilbi, Thierry Soldati, Pierre Cosson Transcriptional Responses of Exposed to Different Classes of Bacteria. Frontiers in microbiology, 11 (2020) doi: 10.3389/fmicb.2020.00410
Lucia L Prieto-Godino, Ana F Silbering, Mohammed A Khallaf, Steeve Cruchet, Karolina Bojkowska, Sylvain Pradervand, Bill S Hansson, Markus Knaden, Richard Benton Functional integration of "undead" neurons in the olfactory system. Science advances, 6 (2020) doi: 10.1126/sciadv.aaz7238
Anne-Lyse Ducrest, Samuel Neuenschwander, Emanuel Schmid-Siegert, Marco Pagni, Clément Train, David Dylus, Yannis Nevers, Alex Warwick Vesztrocy, Luis M San-Jose, Mélanie Dupasquier, Christophe Dessimoz, Ioannis Xenarios, Alexandre Roulin, Jérôme Goudet New genome assembly of the barn owl (). Ecology and evolution, 10 (2020) doi: 10.1002/ece3.5991
Satoshi Fujita, Damien De Bellis, Kai H Edel, Philipp Köster, Tonni Grube Andersen, Emanuel Schmid-Siegert, Valérie Dénervaud Tendon, Alexandre Pfister, Peter Marhavý, Robertas Ursache, Verónica G Doblas, Marie Barberon, Jean Daraspe, Audrey Creff, Gwyneth Ingram, Jörg Kudla, Niko Geldner SCHENGEN receptor module drives localized ROS production and lignification in plant roots. The EMBO journal (2020) doi: 10.15252/embj.2019103894
Chloe Chong, Markus Müller, HuiSong Pak, Dermot Harnett, Florian Huber, Delphine Grun, Marion Leleu, Aymeric Auger, Marion Arnaud, Brian J Stevenson, Justine Michaux, Ilija Bilic, Antje Hirsekorn, Lorenzo Calviello, Laia Simó-Riudalbas, Evarist Planet, Jan Lubiński, Marta Bryśkiewicz, Maciej Wiznerowicz, Ioannis Xenarios, Lin Zhang, Didier Trono, Alexandre Harari, Uwe Ohler, George Coukos, Michal Bassani-Sternberg Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes. Nature communications, 11 (2020) doi: 10.1038/s41467-020-14968-9
Tiziana Caputo, Van Du T Tran, Nasim Bararpour, Carine Winkler, Gabriela Aguileta, Khanh Bao Trang, Greta M P Giordano Attianese, Anne Wilson, Aurelien Thomas, Marco Pagni, Nicolas Guex, Béatrice Desvergne, Federica Gilardi Anti-adipogenic signals at the onset of obesity-related inflammation in white adipose tissue. Cellular and molecular life sciences : CMLS (2020) doi: 10.1007/s00018-020-03485-z
Sophie Rodius, Niek de Klein, Céline Jeanty, Héctor Sánchez-Iranzo, Isaac Crespo, Mark Ibberson, Ioannis Xenarios, Gunnar Dittmar, Nadia Mercader, Simone P Niclou, Francisco Azuaje Fisetin protects against cardiac cell death through reduction of ROS production and caspases activity. Scientific reports, 10 (2020) doi: 10.1038/s41598-020-59894-4
Pierre Fontana, Mark Ibberson, Brian Stevenson, Leonore Wigger, Youssef Daali, Anne Niknejad, François Mach, Mylène Docquier, Ioannis Xenarios, Thomas Cuisset, Marie-Christine Alessi, Jean-Luc Reny Contribution of exome sequencing to the identification of genes involved in the response to clopidogrel in cardiovascular patients. Journal of thrombosis and haemostasis : JTH (2020) doi: 10.1111/jth.14776
Romain Savary, Cindy Dupuis, Frédéric G Masclaux, Ivan D Mateus, Edward C Rojas, Ian R Sanders Genetic variation and evolutionary history of a mycorrhizal fungus regulate the currency of exchange in symbiosis with the food security crop cassava. The ISME journal (2020) doi: 10.1038/s41396-020-0606-6
Amel Bekkar, Anita Nasrallah, Nicolas Guex, Lluis Fajas, Ioannis Xenarios, Isabel C Lopez-Mejia PamgeneAnalyzeR: open and reproducible pipeline for kinase profiling. Bioinformatics (Oxford, England) (2020) doi: 10.1093/bioinformatics/btz858
Harmonie Dehaene, Viviane Praz, Philippe Lhôte, Maykel Lopes, Winship Herr THAP11F80L cobalamin disorder-associated mutation reveals normal and pathogenic THAP11 functions in gene expression and cell proliferation. PloS one, 15 (2020) doi: 10.1371/journal.pone.0224646

Pénélope A Andreux, William Blanco-Bose, Dongryeol Ryu, Frédéric Burdet, Mark Ibberson, Patrick Aebischer, Johan Auwerx, Anurag Singh, Chris Rinsch The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. Nature metabolism, 1 (2019) doi: 10.1038/s42255-019-0073-4
Frédéric G Masclaux, Tania Wyss, Marco Pagni, Pawel Rosikiewicz, Ian R Sanders Investigating unexplained genetic variation and its expression in the arbuscular mycorrhizal fungus Rhizophagus irregularis: A comparison of whole genome and RAD sequencing data. PloS one, 14 (2019) doi: 10.1371/journal.pone.0226497
Charlotte N Hor, Jake Yeung, Maxime Jan, Yann Emmenegger, Jeffrey Hubbard, Ioannis Xenarios, Felix Naef, Paul Franken Sleep-wake-driven and circadian contributions to daily rhythms in gene expression and chromatin accessibility in the murine cortex. Proceedings of the National Academy of Sciences of the United States of America (2019) doi: 10.1073/pnas.1910590116
Alice Newey, Beatrice Griffiths, Justine Michaux, Hui Song Pak, Brian J Stevenson, Andrew Woolston, Maria Semiannikova, Georgia Spain, Louise J Barber, Nik Matthews, Sheela Rao, David Watkins, Ian Chau, George Coukos, Julien Racle, David Gfeller, Naureen Starling, David Cunningham, Michal Bassani-Sternberg, Marco Gerlinger Immunopeptidomics of colorectal cancer organoids reveals a sparse HLA class I neoantigen landscape and no increase in neoantigens with interferon or MEK-inhibitor treatment. Journal for immunotherapy of cancer, 7 (2019) doi: 10.1186/s40425-019-0769-8
Lionel O Mavoungou, Samuel Neuenschwander, Uyen Pham, Pavithra S Iyer, Nicolas Mermod Characterization of mesoangioblast cell fate and improved promyogenic potential of a satellite cell-like subpopulation upon transplantation in dystrophic murine muscles. Stem cell research, 41 (2019) doi: 10.1016/j.scr.2019.101619
Maxime Jan, Nastassia Gobet, Shanaz Diessler, Paul Franken, Ioannis Xenarios A multi-omics digital research object for the genetics of sleep regulation. Scientific data, 6 (2019) doi: 10.1038/s41597-019-0171-x
Pierre-Olivier Duroy, Sandra Bosshard, Emanuel Schmid-Siegert, Samuel Neuenschwander, Ghislaine Arib, Philippe Lemercier, Jacqueline Masternak, Lucien Roesch, Flavien Buron, Pierre-Alain Girod, Ioannis Xenarios, Nicolas Mermod Characterization and mutagenesis of Chinese hamster ovary cells endogenous retroviruses to inactivate viral particle release. Biotechnology and bioengineering (2019) doi: 10.1002/bit.27200
Isha Hashmi, Christophe Paul, Andrej Al-Dourobi, Frederic Sandoz, Priscilla Deschamps, Thomas Junier, Pilar Junier, Saskia Bindschedler Comparison of the plant growth-promotion performance of a consortium of Bacilli inoculated as endospores or as vegetative cells. FEMS microbiology ecology, 95 (2019) doi: 10.1093/femsec/fiz147
Marko Barovic, Marius Distler, Eyke Schöniger, Nicole Radisch, Daniela Aust, Jürgen Weitz, Mark Ibberson, Anke M Schulte, Michele Solimena Metabolically phenotyped pancreatectomized patients as living donors for the study of islets in health and diabetes. Molecular metabolism, 27 (2019) doi: 10.1016/j.molmet.2019.06.006
Bernard Thorens, Ana Rodriguez, Céline Cruciani-Guglielmacci, Leonore Wigger, Mark Ibberson, Christophe Magnan Use of preclinical models to identify markers of type 2 diabetes susceptibility and novel regulators of insulin secretion - A step towards precision medicine. Molecular metabolism, 27 (2019) doi: 10.1016/j.molmet.2019.06.008
Noémie Matthey, Sandrine Stutzmann, Candice Stoudmann, Nicolas Guex, Christian Iseli, Melanie Blokesch Neighbor predation linked to natural competence fosters the transfer of large genomic regions in . eLife, 8 (2019) doi: 10.7554/eLife.48212
Tony Teav, Héctor Gallart-Ayala, Vera van der Velpen, Florence Mehl, Hugues Henry, Julijana Ivanisevic Merged Targeted Quantification and Untargeted Profiling for Comprehensive Assessment of Acylcarnitine and Amino Acid Metabolism. Analytical chemistry (2019) doi: 10.1021/acs.analchem.9b02373
Leonore Wigger, Cristina Casals-Casas, Michaël Baruchet, Khanh B Trang, Sylvain Pradervand, Aurélien Naldi, Béatrice Desvergne System analysis of cross-talk between nuclear receptors reveals an opposite regulation of the cell cycle by LXR and FXR in human HepaRG liver cells. PloS one, 14 (2019) doi: 10.1371/journal.pone.0220894
Elena Sügis, Jerome Dauvillier, Anna Leontjeva, Priit Adler, Valerie Hindie, Thomas Moncion, Vincent Collura, Rachel Daudin, Yann Loe-Mie, Yann Herault, Jean-Charles Lambert, Henning Hermjakob, Tal Pupko, Jean-Christophe Rain, Ioannis Xenarios, Jaak Vilo, Michel Simonneau, Hedi Peterson HENA, heterogeneous network-based data set for Alzheimer's disease. Scientific data, 6 (2019) doi: 10.1038/s41597-019-0152-0
A Luraschi, S Richard, J M G C F Almeida, M Pagni, M T Cushion, P M Hauser Expression and Immunostaining Analyses Suggest that Primary Homothallism Involves Trophic Cells Displaying Both Plus and Minus Pheromone Receptors. mBio, 10 (2019) doi: 10.1128/mBio.01145-19
Frédéric Fumeron, Anthony Nicolas, Jean-Philippe Bastard, Soraya Fellahi, Léonore Wigger, Mark Ibberson, Céline Cruciani-Guglielmacci, Hervé Le Stunff, Gilberto Velho, Christophe Magnan, Michel Marre, Beverley Balkau, Ronan Roussel Dairy consumption is associated with lower plasma dihydroceramides in women from the D.E.S.I.R. cohort. Diabetes & metabolism (2019) doi: 10.1016/j.diabet.2019.06.002
Piero Marchetti, Anke M Schulte, Lorella Marselli, Eyke Schoniger, Marco Bugliani, Werner Kramer, Lut Overbergh, Susanne Ullrich, Anna L Gloyn, Mark Ibberson, Guy Rutter, Philippe Froguel, Leif Groop, Mark I McCarthy, Francesco Dotta, Raphael Scharfmann, Christophe Magnan, Decio L Eizirik, Chantal Mathieu, Miriam Cnop, Bernard Thorens, Michele Solimena Fostering improved human islet research: a European perspective. Diabetologia (2019) doi: 10.1007/s00125-019-4911-4
Sten Ilmjärv, Fiona Augsburger, Jerven Tjalling Bolleman, Robin Liechti, Alan James Bridge, Jenny Sandström, Vincent Jaquet, Ioannis Xenarios, Karl-Heinz Krause Navigating in vitro bioactivity data by investigating available resources using model compounds. Scientific data, 6 (2019) doi: 10.1038/s41597-019-0046-1
Paul A Saunders, Samuel Neuenschwander, Nicolas Perrin Impact of deleterious mutations, sexually antagonistic selection, and mode of recombination suppression on transitions between male and female heterogamety. Heredity (2019) doi: 10.1038/s41437-019-0225-z
Amna Khamis, Mickaël Canouil, Afshan Siddiq, Hutokshi Crouch, Mario Falchi, Manon von Bulow, Florian Ehehalt, Lorella Marselli, Marius Distler, Daniela Richter, Jürgen Weitz, Krister Bokvist, Ioannis Xenarios, Bernard Thorens, Anke M Schulte, Mark Ibberson, Amelie Bonnefond, Piero Marchetti, Michele Solimena, Philippe Froguel Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes. Molecular metabolism (2019) doi: 10.1016/j.molmet.2019.03.004
Florian R Kirchner, Katharina Littringer, Simon Altmeier, Van Du T Tran, Franziska Schönherr, Christina Lemberg, Marco Pagni, Dominique Sanglard, Nicole Joller, Salomé LeibundGut-Landmann Persistence of in the Oral Mucosa Induces a Curbed Inflammatory Host Response That Is Independent of Immunosuppression. Frontiers in immunology, 10 (2019) doi: 10.3389/fimmu.2019.00330
Samuel Neuenschwander, Frédéric Michaud, Jérôme Goudet QuantiNemo 2: a Swiss knife to simulate complex demographic and genetic scenarios, forward and backward in time. Bioinformatics (Oxford, England), 35 (2019) doi: 10.1093/bioinformatics/bty737
Christophe Paul, Sevasti Filippidou, Isha Jamil, Wafa Kooli, Geoffrey L House, Aislinn Estoppey, Mathilda Hayoz, Thomas Junier, Fabio Palmieri, Tina Wunderlin, Anael Lehmann, Saskia Bindschedler, Torsten Vennemann, Patrick S G Chain, Pilar Junier Bacterial spores, from ecology to biotechnology. Advances in applied microbiology, 106 (2019) doi: 10.1016/bs.aambs.2018.10.002
Sevasti Filippidou, Thomas Junier, Tina Wunderlin, Wafa M Kooli, Ilona Palmieri, Andrej Al-Dourobi, Veronica Molina, Reto Lienhard, Jorge E Spangenberg, Shannon L Johnson, Patrick S G Chain, Cristina Dorador, Pilar Junier Adaptive Strategies in a Poly-Extreme Environment: Differentiation of Vegetative Cells in and Resistance to Extreme Conditions. Frontiers in microbiology, 10 (2019) doi: 10.3389/fmicb.2019.00102
Emma Ricart, Valérie Leclère, Areski Flissi, Markus Mueller, Maude Pupin, Frédérique Lisacek rBAN: retro-biosynthetic analysis of nonribosomal peptides. Journal of cheminformatics, 11 (2019) doi: 10.1186/s13321-019-0335-x
Phing Chian Chai, Steeve Cruchet, Leonore Wigger, Richard Benton Sensory neuron lineage mapping and manipulation in the Drosophila olfactory system. Nature communications, 10 (2019) doi: 10.1038/s41467-019-08345-4
Ivan D Mateus, Frédéric G Masclaux, Consolée Aletti, Edward C Rojas, Romain Savary, Cindy Dupuis, Ian R Sanders Dual RNA-seq reveals large-scale non-conserved genotype × genotype-specific genetic reprograming and molecular crosstalk in the mycorrhizal symbiosis. The ISME journal (2019) doi: 10.1038/s41396-018-0342-3

Pawel Dabrowski-Tumanski, Pawel Rubach, Dimos Goundaroulis, Julien Dorier, Piotr Sulkowski, Kenneth C Millett, Eric J Rawdon, Andrzej Stasiak, Joanna I Sulkowska KnotProt 2.0: a database of proteins with knots and other entangled structures. Nucleic acids research (2018) doi: 10.1093/nar/gky1140
Van Du T Tran, Sébastien Moretti, Alix T Coste, Sara Amorim-Vaz, Dominique Sanglard, Marco Pagni Condition-specific series of metabolic sub-networks and its application for gene set enrichment analysis. Bioinformatics (Oxford, England) (2018) doi: 10.1093/bioinformatics/bty929
Dusan Racko, Fabrizio Benedetti, Julien Dorier, Andrzej Stasiak Are TADs supercoiled? Nucleic acids research (2018) doi: 10.1093/nar/gky1091
Sarah Schmid, Samuel Neuenschwander, Camille Pitteloud, Gerald Heckel, Mila Pajkovic, Raphaël Arlettaz, Nadir Alvarez Spatial and temporal genetic dynamics of the grasshopper revealed by museum genomics. Ecology and evolution, 8 (2018) doi: 10.1002/ece3.3699
Thierry Lombardot, Anne Morgat, Kristian B Axelsen, Lucila Aimo, Nevila Hyka-Nouspikel, Anne Niknejad, Alex Ignatchenko, Ioannis Xenarios, Elisabeth Coudert, Nicole Redaschi, Alan Bridge Updates in Rhea: SPARQLing biochemical reaction data. Nucleic acids research (2018) doi: 10.1093/nar/gky876
Thibault Robin, Amos Bairoch, Markus Müller, Frédérique Lisacek, Lydie Lane Large-Scale Reanalysis of Publicly Available HeLa Cell Proteomics Data in the Context of the Human Proteome Project. Journal of proteome research (2018) doi: 10.1021/acs.jproteome.8b00392
Felicia Gerst, Benjamin A Jaghutriz, Harald Staiger, Anke M Schulte, Estela Lorza-Gil, Gabriele Kaiser, Madhura Panse, Sieglinde Haug, Martin Heni, Monika Schütz, Mandy Stadion, Annette Schürmann, Flavia Marzetta, Mark Ibberson, Bence Sipos, Falko Fend, Thomas Fleming, Peter P Nawroth, Alfred Königsrainer, Silvio Nadalin, Silvia Wagner, Andreas Peter, Andreas Fritsche, Daniela Richter, Michele Solimena, Hans-Ulrich Häring, Susanne Ullrich, Robert Wagner TRThe Expression of Aldolase B in Islets is Negatively Associated with Insulin Secretion in Humans. The Journal of clinical endocrinology and metabolism (2018) doi: 10.1210/jc.2018-00791
Roman Mylonas, Ilan Beer, Christian Iseli, Chloe Chong, Hui-Song Pak, David Gfeller, George Coukos, Ioannis Xenarios, Markus Müller, Michal Bassani-Sternberg Estimating the Contribution of Proteasomal Spliced Peptides to the HLA-I Ligandome. Molecular & cellular proteomics : MCP (2018) doi: 10.1074/mcp.RA118.000877
Shanaz Diessler, Maxime Jan, Yann Emmenegger, Nicolas Guex, Benita Middleton, Debra J Skene, Mark Ibberson, Frederic Burdet, Lou Götz, Marco Pagni, Martial Sankar, Robin Liechti, Charlotte N Hor, Ioannis Xenarios, Paul Franken A systems genetics resource and analysis of sleep regulation in the mouse. PLoS biology, 16 (2018) doi: 10.1371/journal.pbio.2005750
Christophe Paul, Zhanna Bayrychenko, Thomas Junier, Sevasti Filippidou, Karin Beck, Matthieu Bueche, Gilbert Greub, Helmut Bürgmann, Pilar Junier Dissemination of antibiotic resistance genes associated with the sporobiota in sediments impacted by wastewater. PeerJ, 6 (2018) doi: 10.7717/peerj.4989
Paul A Saunders, Samuel Neuenschwander, Nicolas Perrin Sex chromosome turnovers and genetic drift: A simulation study. Journal of evolutionary biology (2018) doi: 10.1111/jeb.13336
Jennie R Lill, Peter A van Veelen, Stefan Tenzer, Arie Admon, Etienne Caron, Josh Elias, Albert J R Heck, Miguel Marcilla, Fabio Marino, Markus Müller, Bjoern Peters, Anthony Purcell, Alessandro Sette, Theo Sturm, Nicola Ternette, Juan Antonio Vizcaíno, Michal Bassani-Sternberg Minimal Information About an Immuno-Peptidomics Experiment (MIAIPE). Proteomics (2018) doi: 10.1002/pmic.201800110
Lara Bellini, Mélanie Campana, Claude Rouch, Marta Chacinska, Marco Bugliani, Kelly Meneyrol, Isabelle Hainault, Véronique Lenoir, Jessica Denom, Julien Véret, Nadim Kassis, Bernard Thorens, Mark Ibberson, Piero Marchetti, Agnieszka Blachnio-Zabielska, Céline Cruciani-Guglielmacci, Carina Prip-Buus, Christophe Magnan, Hervé Le Stunff Protective role of the ELOVL2/docosahexaenoic acid axis in glucolipotoxicity-induced apoptosis in rodent beta cells and human islets. Diabetologia (2018) doi: 10.1007/s00125-018-4629-8
Ousmane H Cissé, Liang Ma, Da Wei Huang, Pavel P Khil, John P Dekker, Geetha Kutty, Lisa Bishop, Yueqin Liu, Xilong Deng, Philippe M Hauser, Marco Pagni, Vanessa Hirsch, Richard A Lempicki, Jason E Stajich, Christina A Cuomo, Joseph A Kovacs Comparative Population Genomics Analysis of the Mammalian Fungal Pathogen . mBio, 9 (2018) doi: 10.1128/mBio.00381-18
Julien Dorier, Dimos Goundaroulis, Fabrizio Benedetti, Andrzej Stasiak Knoto-ID: a tool to study the entanglement of open protein chains using the concept of knotoids. Bioinformatics (Oxford, England) (2018) doi: 10.1093/bioinformatics/bty365
Amel Bekkar, Anne Estreicher, Anne Niknejad, Cristina Casals-Casas, Alan Bridge, Ioannis Xenarios, Julien Dorier, Isaac Crespo Expert curation for building network-based dynamical models: a case study on atherosclerotic plaque formation. Database : the journal of biological databases and curation, 2018 (2018) doi: 10.1093/database/bay031
Frédéric G Masclaux, Tania Wyss, Ivan D Mateus-Gonzalez, Consolée Aletti, Ian R Sanders Variation in allele frequencies at the bg112 locus reveals unequal inheritance of nuclei in a dikaryotic isolate of the fungus Rhizophagus irregularis. Mycorrhiza (2018) doi: 10.1007/s00572-018-0834-z
Wencke Walter, Laura Alonso-Herranz, Verdiana Trappetti, Isaac Crespo, Mark Ibberson, Marta Cedenilla, Anna Karaszewska, Vanessa Núñez, Ioannis Xenarios, Alicia G Arroyo, Fátima Sánchez-Cabo, Mercedes Ricote Deciphering the Dynamic Transcriptional and Post-transcriptional Networks of Macrophages in the Healthy Heart and after Myocardial Injury. Cell reports, 23 (2018) doi: 10.1016/j.celrep.2018.03.029
S Richard, J M G C F Almeida, O H Cissé, A Luraschi, O Nielsen, M Pagni, P M Hauser Functional and Expression Analyses of theGenes Suggest Obligate Sexuality through Primary Homothallism within Host Lungs. mBio, 9 (2018) doi: 10.1128/mBio.02201-17
Ricardo Kanitz, Elsa G Guillot, Sylvain Antoniazza, Samuel Neuenschwander, Jérôme Goudet Complex genetic patterns in human arise from a simple range-expansion model over continental landmasses. PloS one, 13 (2018) doi: 10.1371/journal.pone.0192460
Laura Madueño, Christophe Paul, Thomas Junier, Zhanna Bayrychenko, Sevasti Filippidou, Karin Beck, Gilbert Greub, Helmut Bürgmann, Pilar Junier A historical legacy of antibiotic utilization on bacterial seed banks in sediments. PeerJ, 6 (2018) doi: 10.7717/peerj.4197

Dimos Goundaroulis, Neslihan Gügümcü, Sofia Lambropoulou, Julien Dorier, Andrzej Stasiak, Louis Kauffman Topological Models for Open-Knotted Protein Chains Using the Concepts of Knotoids and Bonded Knotoids. Polymers, 9 (2017) doi: 10.3390/polym9090444
Shilpi Minocha, Dominic Villeneuve, Leonor Rib, Catherine Moret, Nicolas Guex, Winship Herr Segregated hepatocyte proliferation and metabolic states within the regenerating mouse liver. Hepatology communications, 1 (2017) doi: 10.1002/hep4.1102
Sarah Schmid, Samuel Neuenschwander, Camille Pitteloud, Gerald Heckel, Mila Pajkovic, Raphaël Arlettaz, Nadir Alvarez Spatial and temporal genetic dynamics of the grasshopper Oedaleus decorus revealed by museum genomics Authors Ecol Evol., 00:1–16 (2017) doi: https://doi.org/10.1002/ece3.3699
Elisa Cavoto, Samuel Neuenschwander, Jérôme Goudet, Nicolas Perrin Sex-antagonistic genes, XY recombination, and feminized Y chromosomes. Journal of evolutionary biology (2017) doi: 10.1111/jeb.13235
Julien Faget, Svenja Groeneveld, Gael Boivin, Martial Sankar, Nadine Zangger, Miguel Garcia, Nicolas Guex, Inti Zlobec, Loïc Steiner, Alessandra Piersigilli, Ioannis Xenarios, Etienne Meylan Neutrophils and Snail Orchestrate the Establishment of a Pro-tumor Microenvironment in Lung Cancer. Cell reports, 21 (2017) doi: 10.1016/j.celrep.2017.11.052
Emanuel Schmid-Siegert, Namrata Sarkar, Christian Iseli, Sandra Calderon, Caroline Gouhier-Darimont, Jacqueline Chrast, Pietro Cattaneo, Frédéric Schütz, Laurent Farinelli, Marco Pagni, Michel Schneider, Jérémie Voumard, Michel Jaboyedoff, Christian Fankhauser, Christian S Hardtke, Laurent Keller, John R Pannell, Alexandre Reymond, Marc Robinson-Rechavi, Ioannis Xenarios, Philippe Reymond Low number of fixed somatic mutations in a long-lived oak tree. Nature plants, 3 (2017) doi: 10.1038/s41477-017-0066-9
Érika Cosset, Sten Ilmjärv, Valérie Dutoit, Kathryn Elliott, Tami von Schalscha, Maria F Camargo, Alexander Reiss, Toshiro Moroishi, Laetitia Seguin, German Gomez, Jung-Soon Moo, Olivier Preynat-Seauve, Karl-Heinz Krause, Hervé Chneiweiss, Jann N Sarkaria, Kun-Liang Guan, Pierre-Yves Dietrich, Sara M Weis, Paul S Mischel, David A Cheresh Glut3 Addiction Is a Druggable Vulnerability for a Molecularly Defined Subpopulation of Glioblastoma. Cancer cell (2017) doi: 10.1016/j.ccell.2017.10.016
Michele Solimena, Anke M Schulte, Lorella Marselli, Florian Ehehalt, Daniela Richter, Manuela Kleeberg, Hassan Mziaut, Klaus-Peter Knoch, Julia Parnis, Marco Bugliani, Afshan Siddiq, Anne Jörns, Frédéric Burdet, Robin Liechti, Mara Suleiman, Daniel Margerie, Farooq Syed, Marius Distler, Robert Grützmann, Enrico Petretto, Aida Moreno-Moral, Carolin Wegbrod, Anke Sönmez, Katja Pfriem, Anne Friedrich, Jörn Meinel, Claes B Wollheim, Gustavo B Baretton, Raphael Scharfmann, Everson Nogoceke, Ezio Bonifacio, Dorothée Sturm, Birgit Meyer-Puttlitz, Ugo Boggi, Hans-Detlev Saeger, Franco Filipponi, Mathias Lesche, Paolo Meda, Andreas Dahl, Leonore Wigger, Ioannis Xenarios, Mario Falchi, Bernard Thorens, Jürgen Weitz, Krister Bokvist, Sigurd Lenzen, Guy A Rutter, Philippe Froguel, Manon von Bülow, Mark Ibberson, Piero Marchetti Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes. Diabetologia (2017) doi: 10.1007/s00125-017-4500-3
Dusan Racko, Fabrizio Benedetti, Julien Dorier, Andrzej Stasiak Transcription-induced supercoiling as the driving force of chromatin loop extrusion during formation of TADs in interphase chromosomes. Nucleic acids research (2017) doi: 10.1093/nar/gkx1123
Emanuel Schmid-Siegert, Sophie Richard, Amanda Luraschi, Konrad Mühlethaler, Marco Pagni, Philippe M Hauser Mechanisms of Surface Antigenic Variation in the Human Pathogenic Fungus Pneumocystis jirovecii. mBio, 8 (2017) doi: 10.1128/mBio.01470-17
Markus Müller, David Gfeller, George Coukos, Michal Bassani-Sternberg 'Hotspots' of Antigen Presentation Revealed by Human Leukocyte Antigen Ligandomics for Neoantigen Prioritization. Frontiers in immunology, 8 (2017) doi: 10.3389/fimmu.2017.01367
Anna Motterle, Sonia Gattesco, Marie-Line Peyot, Jonathan Lou S Esguerra, Ana Gomez-Ruiz, D Ross Laybutt, Patrick Gilon, Frédéric Burdet, Mark Ibberson, Lena Eliasson, Marc Prentki, Romano Regazzi Identification of islet-enriched long non-coding RNAs contributing to β-cell failure in type 2 diabetes. Molecular metabolism, 6 (2017) doi: 10.1016/j.molmet.2017.08.005
Michael E Hughes, Katherine C Abruzzi, Ravi Allada, Ron Anafi, Alaaddin Bulak Arpat, Gad Asher, Pierre Baldi, Charissa de Bekker, Deborah Bell-Pedersen, Justin Blau, Steve Brown, M Fernanda Ceriani, Zheng Chen, Joanna C Chiu, Juergen Cox, Alexander M Crowell, Jason P DeBruyne, Derk-Jan Dijk, Luciano DiTacchio, Francis J Doyle, Giles E Duffield, Jay C Dunlap, Kristin Eckel-Mahan, Karyn A Esser, Garret A FitzGerald, Daniel B Forger, Lauren J Francey, Ying-Hui Fu, Frédéric Gachon, David Gatfield, Paul de Goede, Susan S Golden, Carla Green, John Harer, Stacey Harmer, Jeff Haspel, Michael H Hastings, Hanspeter Herzel, Erik D Herzog, Christy Hoffmann, Christian Hong, Jacob J Hughey, Jennifer M Hurley, Horacio O de la Iglesia, Carl Johnson, Steve A Kay, Nobuya Koike, Karl Kornacker, Achim Kramer, Katja Lamia, Tanya Leise, Scott A Lewis, Jiajia Li, Xiaodong Li, Andrew C Liu, Jennifer J Loros, Tami A Martino, Jerome S Menet, Martha Merrow, Andrew J Millar, Todd Mockler, Felix Naef, Emi Nagoshi, Michael N Nitabach, Maria Olmedo, Dmitri A Nusinow, Louis J Ptáček, David Rand, Akhilesh B Reddy, Maria S Robles, Till Roenneberg, Michael Rosbash, Marc D Ruben, Samuel S C Rund, Aziz Sancar, Paolo Sassone-Corsi, Amita Sehgal, Scott Sherrill-Mix, Debra J Skene, Kai-Florian Storch, Joseph S Takahashi, Hiroki R Ueda, Han Wang, Charles Weitz, Pål O Westermark, Herman Wijnen, Ying Xu, Gang Wu, Seung-Hee Yoo, Michael Young, Eric Erquan Zhang, Tomasz Zielinski, John B Hogenesch Guidelines for Genome-Scale Analysis of Biological Rhythms. Journal of biological rhythms (2017) doi: 10.1177/0748730417728663
Robin Liechti, Nancy George, Lou Götz, Sara El-Gebali, Anastasia Chasapi, Isaac Crespo, Ioannis Xenarios, Thomas Lemberger SourceData: a semantic platform for curating and searching figures. Nature methods, 14 (2017) doi: 10.1038/nmeth.4471
Romain Savary, Frédéric G Masclaux, Tania Wyss, Germain Droh, Joaquim Cruz Corella, Ana Paula Machado, Joseph B Morton, Ian R Sanders A population genomics approach shows widespread geographical distribution of cryptic genomic forms of the symbiotic fungus Rhizophagus irregularis. The ISME journal (2017) doi: 10.1038/ismej.2017.153
Fabrizio Benedetti, Dusan Racko, Julien Dorier, Yannis Burnier, Andrzej Stasiak Transcription-induced supercoiling explains formation of self-interacting chromatin domains in S. pombe. Nucleic acids research, 45 (2017) doi: 10.1093/nar/gkx716
Dusan Racko, Fabrizio Benedetti, Julien Dorier, Yannis Burnier, Andrzej Stasiak Molecular Dynamics Simulation of Supercoiled, Knotted, and Catenated DNA Molecules, Including Modeling of Action of DNA Gyrase. Methods in molecular biology (Clifton, N.J.), 1624 (2017) doi: 10.1007/978-1-4939-7098-8_24
Luis Vale-Silva, Emmanuel Beaudoing, Van Du T Tran, Dominique Sanglard Comparative Genomics of Two Sequential Candida glabrata Clinical Isolates. G3 (Bethesda, Md.), 7 (2017) doi: 10.1534/g3.117.042887
Dimos Goundaroulis, Julien Dorier, Fabrizio Benedetti, Andrzej Stasiak Studies of global and local entanglements of individual protein chains using the concept of knotoids. Scientific reports, 7 (2017) doi: 10.1038/s41598-017-06649-3
Trinidad Martín-Campos, Roman Mylonas, Alexandre Masselot, Patrice Waridel, Tanja Petricevic, Ioannis Xenarios, Manfredo Quadroni MsViz: A Graphical Software Tool for In-Depth Manual Validation and Quantitation of Post-translational Modifications. Journal of proteome research (2017) doi: 10.1021/acs.jproteome.7b00194
Christian Linke, Anastasia Chasapi, Alberto González-Novo, Istabrak Al Sawad, Silvia Tognetti, Edda Klipp, Mart Loog, Sylvia Krobitsch, Francesc Posas, Ioannis Xenarios, Matteo Barberis A Clb/Cdk1-mediated regulation of Fkh2 synchronizes CLB expression in the budding yeast cell cycle. NPJ systems biology and applications, 3 (2017) doi: 10.1038/s41540-017-0008-1
Violeta Castelo-Szekely, Alaaddin Bulak Arpat, Peggy Janich, David Gatfield Translational contributions to tissue specificity in rhythmic and constitutive gene expression. Genome biology, 18 (2017) doi: 10.1186/s13059-017-1222-2
Riccardo Turrini, Angélique Pabois, Ioannis Xenarios, George Coukos, Jean-François Delaloye, Marie-Agnès Doucey TIE-2 expressing monocytes in human cancers. Oncoimmunology, 6 (2017) doi: 10.1080/2162402X.2017.1303585
Giuseppe Marco Randazzo, David Tonoli, Petra Strajhar, Ioannis Xenarios, Alex Odermatt, Julien Boccard, Serge Rudaz Enhanced metabolite annotation via dynamic retention time prediction: Steroidogenesis alterations as a case study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (2017) doi: 10.1016/j.jchromb.2017.04.032
François Mange, Viviane Praz, Eugenia Migliavacca, Ian M Willis, Frédéric Schütz, Nouria Hernandez, , Nouria Hernandez, Mauro Delorenzi, Bart Deplancke, Béatrice Desvergne, Nicolas Guex, Winship Herr, Felix Naef, Jacques Rougemont, Ueli Schibler, Teemu Andersin, Pascal Cousin, Federica Gilardi, Fabienne Lammers, François Mange, Dominic Villeneuve, Fabrice David, Roberto Fabbretti, Philippe Jacquet, Irina Krier, Dmitry Kuznetsov, Marion Leleu, Robin Liechti, Olivier Martin, Eugenia Migliavacca, Aurélien Naldi, Viviane Praz, Leonor Rib, Jonathan Sobel, Volker Vlegel, Ioannis Xenarios Diurnal regulation of RNA polymerase III transcription is under the control of both the feeding-fasting response and the circadian clock. Genome research (2017) doi: 10.1101/gr.217521.116
Céline Cruciani-Guglielmacci, Lara Bellini, Jessica Denom, Masaya Oshima, Neïké Fernandez, Priscilla Normandie-Levi, Xavier P Berney, Nadim Kassis, Claude Rouch, Julien Dairou, Tracy Gorman, David M Smith, Anna Marley, Robin Liechti, Dmitry Kuznetsov, Leonore Wigger, Frédéric Burdet, Anne-Laure Lefèvre, Isabelle Wehrle, Ingo Uphues, Tobias Hildebrandt, Werner Rust, Catherine Bernard, Alain Ktorza, Guy A Rutter, Raphael Scharfmann, Ioannis Xenarios, Hervé Le Stunff, Bernard Thorens, Christophe Magnan, Mark Ibberson Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion. Molecular metabolism, 6 (2017) doi: 10.1016/j.molmet.2017.01.009
Fariza Tahi, Van Du T Tran, Anouar Boucheham In Silico Prediction of RNA Secondary Structure. Methods in molecular biology (Clifton, N.J.), 1543 (2017) doi: 10.1007/978-1-4939-6716-2_7
Cedric Simillion, Robin Liechti, Heidi E L Lischer, Vassilios Ioannidis, Rémy Bruggmann Avoiding the pitfalls of gene set enrichment analysis with SetRank. BMC bioinformatics, 18 (2017) doi: 10.1186/s12859-017-1571-6
Leonore Wigger, Céline Cruciani-Guglielmacci, Anthony Nicolas, Jessica Denom, Neïké Fernandez, Frédéric Fumeron, Pedro Marques-Vidal, Alain Ktorza, Werner Kramer, Anke Schulte, Hervé Le Stunff, Robin Liechti, Ioannis Xenarios, Peter Vollenweider, Gérard Waeber, Ingo Uphues, Ronan Roussel, Christophe Magnan, Mark Ibberson, Bernard Thorens Plasma Dihydroceramides Are Diabetes Susceptibility Biomarker Candidates in Mice and Humans. Cell reports, 18 (2017) doi: 10.1016/j.celrep.2017.02.019
Aleksandre Japaridze, Georgi Muskhelishvili, Fabrizio Benedetti, Agni F M Gavriilidou, Renato Zenobi, Paolo De Los Rios, Giovanni Longo, Giovanni Dietler Hyperplectonemes: A Higher Order Compact and Dynamic DNA Self-Organization. Nano letters (2017) doi: 10.1021/acs.nanolett.6b05294
Gaelle R Carrat, Ming Hu, Marie-Sophie Nguyen-Tu, Pauline Chabosseau, Kyle J Gaulton, Martijn van de Bunt, Afshan Siddiq, Mario Falchi, Matthias Thurner, Mickaël Canouil, Francois Pattou, Isabelle Leclerc, Timothy J Pullen, Matthew C Cane, Priyanka Prabhala, William Greenwald, Anke Schulte, Piero Marchetti, Mark Ibberson, Patrick E MacDonald, Jocelyn E Manning Fox, Anna L Gloyn, Philippe Froguel, Michele Solimena, Mark I McCarthy, Guy A Rutter Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice. American journal of human genetics (2017) doi: 10.1016/j.ajhg.2017.01.011
Jade Leiba, Ayman Sabra, Romain Bodinier, Anna Marchetti, Wanessa C Lima, Astrid Melotti, Jackie Perrin, Frederic Burdet, Marco Pagni, Thierry Soldati, Emmanuelle Lelong, Pierre Cosson Vps13F links bacterial recognition and intracellular killing in Dictyostelium. Cellular microbiology (2017) doi: 10.1111/cmi.12722

Isaac Crespo, Lou Götz, Robin Liechti, George Coukos, Marie-Agnès Doucey, Ioannis Xenarios Identifying biological mechanisms for favorable cancer prognosis using non-hypothesis-driven iterative survival analysis. NPJ systems biology and applications, 2 (2016) doi: 10.1038/npjsba.2016.37
Anne Morgat, Thierry Lombardot, Kristian B Axelsen, Lucila Aimo, Anne Niknejad, Nevila Hyka-Nouspikel, Elisabeth Coudert, Monica Pozzato, Marco Pagni, Sébastien Moretti, Steven Rosanoff, Joseph Onwubiko, Lydie Bougueleret, Ioannis Xenarios, Nicole Redaschi, Alan Bridge Updates in Rhea - an expert curated resource of biochemical reactions. Nucleic acids research (2016) doi: 10.1093/nar/gkw1299
Madhur S Dhingra, Jean Artois, Timothy P Robinson, Catherine Linard, Celia Chaiban, Ioannis Xenarios, Robin Engler, Robin Liechti, Dimitry Kuznetsov, Xiangming Xiao, Sophie Von Dobschuetz, Filip Claes, Scott H Newman, Gwenaëlle Dauphin, Marius Gilbert Global mapping of highly pathogenic avian influenza H5N1 and H5Nx clade 2.3.4.4 viruses with spatial cross-validation. eLife, 5 (2016) doi: 10.7554/eLife.19571
Sevasti Filippidou, Tina Wunderlin, Thomas Junier, Nicole Jeanneret, Cristina Dorador, Veronica Molina, David R Johnson, Pilar Junier A Combination of Extreme Environmental Conditions Favor the Prevalence of Endospore-Forming Firmicutes. Frontiers in microbiology, 7 (2016) pmid: 27857706
Amanda Luraschi, Ousmane H Cissé, Marco Pagni, Philippe M Hauser Identification and Functional Ascertainment of the Pneumocystis jirovecii Potential Drug Targets Gsc1 and Kre6 Involved in Glucan Synthesis. The Journal of eukaryotic microbiology (2016) doi: 10.1111/jeu.12385
Harsha D Devalla, Roselle Gélinas, Elhadi H Aburawi, Abdelaziz Beqqali, Philippe Goyette, Christian Freund, Marie-A Chaix, Rafik Tadros, Hui Jiang, Antony Le Béchec, Jantine J Monshouwer-Kloots, Tom Zwetsloot, Georgios Kosmidis, Frédéric Latour, Azadeh Alikashani, Maaike Hoekstra, Jurg Schlaepfer, Christine L Mummery, Brian Stevenson, Zoltan Kutalik, Antoine Af de Vries, Léna Rivard, Arthur Am Wilde, Mario Talajic, Arie O Verkerk, Lihadh Al-Gazali, John D Rioux, Zahurul A Bhuiyan, Robert Passier TECRL, a new life-threatening inherited arrhythmia gene associated with overlapping clinical features of both LQTS and CPVT. EMBO molecular medicine (2016) doi: 10.15252/emmm.201505719
Alexandre Picard, Josselin Soyer, Xavier Berney, David Tarussio, Simon Quenneville, Maxime Jan, Eric Grouzmann, Frédéric Burdet, Mark Ibberson, Bernard Thorens A Genetic Screen Identifies Hypothalamic Fgf15 as a Regulator of Glucagon Secretion. Cell reports, 17 (2016) doi: 10.1016/j.celrep.2016.10.041
Van Du T Tran, Niccolò De Coi, Marc Feuermann, Emanuel Schmid-Siegert, Elena-Tatiana Băguţ, Bernard Mignon, Patrice Waridel, Corinne Peter, Sylvain Pradervand, Marco Pagni, Michel Monod RNA Sequencing-Based Genome Reannotation of the Dermatophyte Arthroderma benhamiae and Characterization of Its Secretome and Whole Gene Expression Profile during Infection. mSystems, 1 (2016) pmid: 27822542
Paula Vazquez-Pianzola, Bogdan Schaller, Martino Colombo, Dirk Beuchle, Samuel Neuenschwander, Anne Marcil, Rémy Bruggmann, Beat Suter The mRNA transportome of the BicD/Egl transport machinery. RNA biology (2016) doi: 10.1080/15476286.2016.1251542
Anne Morgat, Thierry Lombardot, Kristian B Axelsen, Lucila Aimo, Anne Niknejad, Nevila Hyka-Nouspikel, Elisabeth Coudert, Monica Pozzato, Marco Pagni, Sébastien Moretti, Steven Rosanoff, Joseph Onwubiko, Lydie Bougueleret, Ioannis Xenarios, Nicole Redaschi, Alan Bridge Updates in rhea-an expert curated resource of biochemical reactions. Nucleic acids research (2016) doi: 10.1093/nar/gkw990
Julien Dorier, Isaac Crespo, Anne Niknejad, Robin Liechti, Martin Ebeling, Ioannis Xenarios Boolean regulatory network reconstruction using literature based knowledge with a genetic algorithm optimization method. BMC bioinformatics, 17 (2016) pmid: 27716031
Mihai Miclaus, Ovidiu Balacescu, Ioan Has, Loredana Balacescu, Voichita Has, Dana Suteu, Samuel Neuenschwander, Irene Keller, Rémy Bruggmann Maize cytolines unmask key nuclear genes that are under the control of retrograde signaling pathways in plants. Genome biology and evolution (2016) pmid: 27702813
Kostyrko K, Neuenschwander S, Junier T, Regamey A, Iseli C, Schmid-Siegert E, Bosshard S, Majocchi S, Le Fourn V, Girod PA, Xenarios I, Mermod N. MAR-mediated transgene integration into permissive chromatin and increased expression by recombination pathway engineering Biotechnol Bioeng. (2016) doi: 10.1002/bit.26086
Jean Artois, Scott H Newman, Madhur S Dhingra, Celia Chaiban, Catherine Linard, Giovanni Cattoli, Isabella Monne, Alice Fusaro, Ioannis Xenarios, Robin Engler, Robin Liechti, Dmitri Kuznetsov, Thanh Long Pham, Tung Nguyen, Van Dong Pham, David Castellan, Sophie Von Dobschuetz, Filip Claes, Gwenaëlle Dauphin, Ken Inui, Marius Gilbert Clade-level Spatial Modelling of HPAI H5N1 Dynamics in the Mekong Region Reveals New Patterns and Associations with Agro-Ecological Factors. Scientific reports, 6 (2016) doi: 10.1038/srep30316
Graziano Pescia, Nicolas Guex, Christian Iseli, Liam Brennan, Magne Osteras, Ioannis Xenarios, Laurent Farinelli, Bernard Conrad Cell-free DNA testing of an extended range of chromosomal anomalies: clinical experience with 6,388 consecutive cases. Genetics in medicine : official journal of the American College of Medical Genetics (2016) doi: 10.1038/gim.2016.72
Pelin O Simsek Kiper, Hiroaki Saito, Francesca Gori, Sheila Unger, Eric Hesse, Kei Yamana, Riku Kiviranta, Nicolas Solban, Jeff Liu, Robert Brommage, Koray Boduroglu, Luisa Bonafé, Belinda Campos-Xavier, Esra Dikoglu, Richard Eastell, Fatma Gossiel, Keith Harshman, Gen Nishimura, Katta M Girisha, Brian J Stevenson, Hiroyuki Takita, Carlo Rivolta, Andrea Superti-Furga, Roland Baron Cortical-Bone Fragility--Insights from sFRP4 Deficiency in Pyle's Disease. The New England journal of medicine, 374 (2016) doi: 10.1056/NEJMoa1509342
Ludovic Telley, Subashika Govindan, Julien Prados, Isabelle Stevant, Serge Nef, Emmanouil Dermitzakis, Alexandre Dayer, Denis Jabaudon Sequential transcriptional waves direct the differentiation of newborn neurons in the mouse neocortex. Science (New York, N.Y.), 351 (2016) doi: 10.1126/science.aad8361
Svetlana Nikolaeva, Camille Ansermet, Gabriel Centeno, Sylvain Pradervand, Vincent Bize, David Mordasini, Hugues Henry, Robert Koesters, Marc Maillard, Olivier Bonny, Natsuko Tokonami, Dmitri Firsov Nephron-Specific Deletion of Circadian Clock Gene Bmal1 Alters the Plasma and Renal Metabolome and Impairs Drug Disposition. Journal of the American Society of Nephrology : JASN (2016) pmid: 27056296
Leonardo Murgiano, Vera Shirokova, Monika Maria Welle, Vidhya Jagannathan, Philippe Plattet, Anna Oevermann, Aldona Pienkowska-Schelling, Daniele Gallo, Arcangelo Gentile, Marja L Mikkola, Cord Drögemüller Correction: Hairless Streaks in Cattle Implicate TSR2 in Early Hair Follicle Formation. PLoS genetics, 12 (2016) doi: 10.1371/journal.pgen.1005688
Philemon Karli, Anna Oevermann, Anina Bauer, Vidhya Jagannathan, Tosso Leeb MFSD8 single-base pair deletion in a Chihuahua with neuronal ceroid lipofuscinosis. Animal genetics (2016) doi: 10.1111/age.12449
Marjo K Hytönen, Meharji Arumilli, Anu K Lappalainen, Marta Owczarek-Lipska, Vidhya Jagannathan, Sruthi Hundi, Elina Salmela, Patrick Venta, Eva Sarkiala, Tarja Jokinen, Daniela Gorgas, Juha Kere, Pekka Nieminen, Cord Drögemüller, Hannes Lohi Molecular Characterization of Three Canine Models of Human Rare Bone Diseases: Caffey, van den Ende-Gupta, and Raine Syndromes. PLoS genetics, 12 (2016) doi: 10.1371/journal.pgen.1006037
Maren Doelle, Keith E Linder, Janna Boche, Vidhya Jagannathan, Tosso Leeb, Monika Linek Initial characterization of stiff skin-like syndrome in West Highland white terriers. Veterinary dermatology, 27 (2016) doi: 10.1111/vde.12316
Jørgen S Agerholm, Fiona Menzi, Fintan J McEvoy, Vidhya Jagannathan, Cord Drögemüller Lethal chondrodysplasia in a family of Holstein cattle is associated with a de novo splice site variant of COL2A1. BMC veterinary research, 12 (2016) doi: 10.1186/s12917-016-0739-z
Sevasti Filippidou, Marion Jaussi, Thomas Junier, Tina Wunderlin, Nicole Jeanneret, Fabio Palmieri, Ilona Palmieri, Ludovic Roussel-Delif, Andrea Vieth-Hillebrand, Alexandra Vetter, Patrick S Chain, Simona Regenspurg, Pilar Junier Anoxybacillus geothermalis sp. nov., a facultative anaerobic endospore-forming bacterium isolated from mineral deposits in a geothermal station. International journal of systematic and evolutionary microbiology (2016) doi: 10.1099/ijsem.0.001125
Aline Dousse, Thomas Junier, Evgeny M Zdobnov CEGA--a catalog of conserved elements from genomic alignments. Nucleic acids research, 44 (2016) doi: 10.1093/nar/gkv1163
Marilena Colaianna, Sten Ilmjärv, Hedi Peterson, Ilse Kern, Stephanie Julien, Mathurin Baquié, Giorgia Pallocca, Sieto Bosgra, Agapios Sachinidis, Jan G Hengstler, Marcel Leist, Karl-Heinz Krause Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay. Archives of toxicology (2016) doi: 10.1007/s00204-016-1690-2
Antonio Rausell, Miguel Muñoz, Raquel Martinez, Thierry Roger, Amalio Telenti, Angela Ciuffi Innate immune defects in HIV permissive cell lines. Retrovirology, 13 (2016) doi: 10.1186/s12977-016-0275-8
Von Dach E, Diene SM, Fankhauser C, Schrenzel J, Harbarth S, François P. Comparative Genomics of Community-Associated Methicillin-Resistant Staphylococcus aureus Shows the Emergence of Clone ST8-USA300 in Geneva, Switzerland. J Infect Dis. , 213:1370-9 (2016) doi: 10.1093/infdis/jiv489
Nathalie van der Mee-Marquet, Seydina M Diene, Fabrice Chopin, Alain Goudeau, Patrice François Enigmatic occurrence of NDM-7 enzyme in the community. International journal of antimicrobial agents, 47 (2016) doi: 10.1016/j.ijantimicag.2016.04.002
Makhlouf AM, Chitikova Z, Pusztaszeri M, Berczy M, Delucinge-Vivier C, Triponez F, Meyer P, Philippe J, Dibner C. Identification of CHEK1, SLC26A4, c-KIT, TPO and TG as new biomarkers for human follicular thyroid carcinoma. Oncotarget. (2016) doi: 10.18632/oncotarget.10166
Sonia Plaza-Wüthrich, Regula Blösch, Abiel Rindisbacher, Gina Cannarozzi, Zerihun Tadele Gibberellin Deficiency Confers Both Lodging and Drought Tolerance in Small Cereals. Frontiers in plant science, 7 (2016) doi: 10.3389/fpls.2016.00643
Zhao H, Frank T, Tan Y, Zhou C, Jabnoune M, Arpat B, Cui H, Huang J, He Z, Poirier Y, Engel KH, Shu Q. Disruption of OsSULTR3;3 reduces phytate and phosphorus concentrations and alters the metabolite profile in rice grains. New Phytol. (2016) doi: 10.1111/nph.13969
Gourgues G, Barré A, Beaudoing E, Weber J, Magdelenat G, Barbe V, Schieck E, Jores J, Vashee S, Blanchard A, Lartigue C, Sirand-Pugnet P. Complete Genome Sequence of Mycoplasma mycoides subsp. mycoides T1/44, a Vaccine Strain against Contagious Bovine Pleuropneumonia. Genome Announc. , 4:pii: e00263-16 (2016) doi: 10.1128/genomeA.00263-16
Degueurce G, D'Errico I, Pich C, Ibberson M, Schütz F, Montagner A, Sgandurra M, Mury L, Jafari P, Boda A, Meunier J, Rezzonico R, Brembilla NC, Hohl D, Kolios A, Hofbauer G, Xenarios I, Michalik L. Identification of a novel PPARβ/δ/miR-21-3p axis in UV-induced skin inflammation. EMBO Mol Med. (2016) doi: 10.15252/emmm.201505384
Druce M, Hulo C, Masson P, Sommer P, Xenarios I, Le Mercier P, De Oliveira T. Improving HIV proteome annotation: new features of BioAfrica HIV Proteomics Resource. Database (Oxford). (2016) doi: 10.1093/database/baw045
Tran Vdu T, Souiai O, Romero-Barrios N, Crespi M, Gautheret D. Detection of generic differential RNA processing events from RNA-seq data. RNA Biol., 13:59-67 (2016) doi: 10.1080/15476286.2015.1118604
Crippa S, Nemir M, Ounzain S, Ibberson M, Berthonneche C, Sarre A, Boisset G, Maison D, Harshman K, Xenarios I, Diviani D, Schorderet D, Pedrazzini T. Comparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways. Cardiovasc Res. (2016) doi: 10.1093/cvr/cvw031
Cattin S, Fellay B, Pradervand S, Trojan A, Ruhstaller T, Rüegg C, Fürstenberger G. Bevacizumab specifically decreases elevated levels of circulating KIT+CD11b+ cells and IL-10 in metastatic breast cancer patients. Oncotarget. (2016) doi: 10.18632/oncotarget.7097
Wege S, Khan GA, Jung JY, Vogiatzaki E, Pradervand S, Aller I, Meyer AJ, Poirier Y. The EXS Domain of PHO1 Participates in the Response of Shoots to Phosphate Deficiency via a Root-to-Shoot Signal. Plant Physiol., 170:385-400 (2016) doi: 10.1104/pp.15.00975
SIB Swiss Institute of Bioinformatics Members. The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases. Nucleic Acids Res. , 44:D27-37 (2016) doi: 10.1093/nar/gkv1310
Fabre G, Garroum I, Mazurek S, Daraspe J, Mucciolo A, Sankar M, Humbel BM, Nawrath C. The ABCG transporter PEC1/ABCG32 is required for the formation of the developing leaf cuticle in Arabidopsis. New Phytol. , 209:192-201 (2016) doi: 10.1111/nph.13608
Shumaila Sayyab, Agnese Viluma, Kerstin Bergvall, Emma Brunberg, Vidhya Jagannathan, Tosso Leeb, Göran Andersson, Tomas F Bergström Whole-Genome Sequencing of a Canine Family Trio Reveals a FAM83G Variant Associated with Hereditary Footpad Hyperkeratosis. G3 (Bethesda, Md.), 6 (2016) doi: 10.1534/g3.115.025643
Ison J, Rapacki K, Ménager H, Kalaš M, Rydza E, Chmura P, Anthon C, Beard N, Berka K, Bolser D, Booth T, Bretaudeau A, Brezovsky J, Casadio R, Cesareni G, Coppens F, Cornell M, Cuccuru G, Davidsen K, Vedova GD, Dogan T, Doppelt-Azeroual O, Emery L, Gasteiger E, Gatter T, Goldberg T, Grosjean M, Grüning B, Helmer-Citterich M, Ienasescu H, Ioannidis V, Jespersen MC, Jimenez R, Juty N, Juvan P, Koch M, Laibe C, Li JW, Licata L, Mareuil F, Mičetić I, Friborg RM, Moretti S, Morris C, Möller S, Nenadic A, Peterson H, Profiti G, Rice P, Romano P, Roncaglia P, Saidi R, Schafferhans A, Schwämmle V, Smith C, Sperotto MM, Stockinger H, Vařeková RS, Tosatto SC, de la Torre V, Uva P, Via A, Yachdav G, Zambelli F, Vriend G, Rost B, Parkinson H, Løngreen P, Brunak S. Tools and data services registry: a community effort to document bioinformatics resources. Nucleic Acids Res., 44:D38-47 (2016) doi: 10.1093/nar/gkv1116
Sophie Rodius, Ganna Androsova, Lou Götz, Robin Liechti, Isaac Crespo, Susanne Merz, Petr V Nazarov, Niek de Klein, Céline Jeanty, Juan M González-Rosa, Arnaud Muller, Francois Bernardin, Simone P Niclou, Laurent Vallar, Nadia Mercader, Mark Ibberson, Ioannis Xenarios, Francisco Azuaje Analysis of the dynamic co-expression network of heart regeneration in the zebrafish. Scientific reports, 6 (2016) doi: 10.1038/srep26822
Andrea Orioli, Viviane Praz, Philippe Lhôte, Nouria Hernandez Human MAF1 targets and represses active RNA polymerase III genes by preventing recruitment rather than inducing long-term transcriptional arrest. Genome research, 26 (2016) doi: 10.1101/gr.201400.115
Clara D M van Karnebeek, Luisa Bonafé, Xiao-Yan Wen, Maja Tarailo-Graovac, Sara Balzano, Beryl Royer-Bertrand, Angel Ashikov, Livia Garavelli, Isabella Mammi, Licia Turolla, Catherine Breen, Dian Donnai, Valerie Cormier, Delphine Heron, Gen Nishimura, Shinichi Uchikawa, Belinda Campos-Xavier, Antonio Rossi, Thierry Hennet, Koroboshka Brand-Arzamendi, Jacob Rozmus, Keith Harshman, Brian J Stevenson, Enrico Girardi, Giulio Superti-Furga, Tammie Dewan, Alissa Collingridge, Jessie Halparin, Colin J Ross, Margot I Van Allen, Andrea Rossi, Udo F Engelke, Leo A J Kluijtmans, Ed van der Heeft, Herma Renkema, Arjan de Brouwer, Karin Huijben, Fokje Zijlstra, Thorben Heisse, Thomas Boltje, Wyeth W Wasserman, Carlo Rivolta, Sheila Unger, Dirk J Lefeber, Ron A Wevers, Andrea Superti-Furga NANS-mediated synthesis of sialic acid is required for brain and skeletal development. Nature genetics (2016) doi: 10.1038/ng.3578
Peggy Janich, Alaaddin Bulak Arpat, Violeta Castelo-Szekely, David Gatfield Analyzing the temporal regulation of translation efficiency in mouse liver. Genomics data, 8 (2016) doi: 10.1016/j.gdata.2016.03.004
Eric J Rawdon, Julien Dorier, Dusan Racko, Kenneth C Millett, Andrzej Stasiak How topoisomerase IV can efficiently unknot and decatenate negatively supercoiled DNA molecules without causing their torsional relaxation. Nucleic acids research (2016) doi: 10.1093/nar/gkw311
Quentin Rougemont, Camille Roux, Samuel Neuenschwander, Jérôme Goudet, Sophie Launey, Guillaume Evanno Reconstructing the demographic history of divergence between European river and brook lampreys using approximate Bayesian computations. PeerJ, 4 (2016) doi: 10.7717/peerj.1910
Sarah L Leake, Marco Pagni, Laurent Falquet, Franco Taroni, Gilbert Greub The salivary microbiome for differentiating individuals: proof of principle. Microbes and infection / Institut Pasteur (2016) doi: 10.1016/j.micinf.2016.03.011
Sylvian Bron, Luc Henry, Eveline Faes-Van't Hull, Riccardo Turrini, Dominique Vanhecke, Nicolas Guex, Assia Ifticene-Treboux, Emanuela Marina Iancu, Aikaterini Semilietof, Nathalie Rufer, Hans-Anton Lehr, Ioannis Xenarios, George Coukos, Jean-François Delaloye, Marie-Agnès Doucey TIE-2-expressing monocytes are lymphangiogenic and associate specifically with lymphatics of human breast cancer. Oncoimmunology, 5 (2016) pmid: 27057438
Adrian M Altenhoff, Brigitte Boeckmann, Salvador Capella-Gutierrez, Daniel A Dalquen, Todd DeLuca, Kristoffer Forslund, Jaime Huerta-Cepas, Benjamin Linard, Cécile Pereira, Leszek P Pryszcz, Fabian Schreiber, Alan Sousa da Silva, Damian Szklarczyk, Clément-Marie Train, Peer Bork, Odile Lecompte, Christian von Mering, Ioannis Xenarios, Kimmen Sjölander, Lars Juhl Jensen, Maria J Martin, Matthieu Muffato, , Toni Gabaldón, Suzanna E Lewis, Paul D Thomas, Erik Sonnhammer, Christophe Dessimoz Standardized benchmarking in the quest for orthologs. Nature methods (2016) doi: 10.1038/nmeth.3830
Gaetano Terrone, Norine Voisin, Ali Abdullah Alfaiz, Gerarda Cappuccio, Giuseppina Vitiello, Nicolas Guex, Alessandra D'Amico, A James Barkovich, Nicola Brunetti-Pierri, Ennio Del Giudice, Alexandre Reymond De novo PIK3R2 variant causes polymicrogyria, corpus callosum hyperplasia and focal cortical dysplasia. European journal of human genetics : EJHG (2016) doi: 10.1038/ejhg.2016.7
Isaac Crespo, Marie-Agnès Doucey, Ioannis Xenarios Social networks help to infer causality in the tumor microenvironment. BMC research notes, 9 (2016) doi: 10.1186/s13104-016-1976-8
Tania Wyss, Frédéric G Masclaux, Pawel Rosikiewicz, Marco Pagni, Ian R Sanders Population genomics reveals that within-fungus polymorphism is common and maintained in populations of the mycorrhizal fungus Rhizophagus irregularis. The ISME journal (2016) doi: 10.1038/ismej.2016.29
Vincent Zoete, Thierry Schuepbach, Christophe Bovigny, Prasad Chaskar, Antoine Daina, Ute F Röhrig, Olivier Michielin Attracting cavities for docking. Replacing the rough energy landscape of the protein by a smooth attracting landscape. Journal of computational chemistry, 37 (2016) doi: 10.1002/jcc.24249
Anne Zufferey, Mark Ibberson, Jean-Luc Reny, Séverine Nolli, Domitille Schvartz, Mylène Docquier, Ioannis Xenarios, Jean-Charles Sanchez, Pierre Fontana New molecular insights into modulation of platelet reactivity in aspirin-treated patients using a network-based approach. Human genetics (2016) doi: 10.1007/s00439-016-1642-1
Martine Emery, Natacha Nanchen, Frédéric Preitner, Mark Ibberson, Raphaël Roduit Biological Characterization of Gene Response to Insulin-Induced Hypoglycemia in Mouse Retina. PloS one, 11 (2016) doi: 10.1371/journal.pone.0150266
Alice Marmugi, Julia Parnis, Xi Chen, LeAnne Carmichael, Julie Hardy, Naila Mannan, Piero Marchetti, Lorenzo Piemonti, Domenico Bosco, Paul Johnson, A M James Shapiro, Céline Cruciani-Guglielmacci, Christophe Magnan, Mark Ibberson, Bernard Thorens, Héctor H Valdivia, Guy A Rutter, Isabelle Leclerc Sorcin links pancreatic β cell lipotoxicity to ER Ca2+ stores. Diabetes (2016) doi: 10.2337/db15-1334
Sébastien Moretti, Olivier Martin, T Van Du Tran, Alan Bridge, Anne Morgat, Marco Pagni MetaNetX/MNXref - reconciliation of metabolites and biochemical reactions to bring together genome-scale metabolic networks. Nucleic acids research, 44 (2016) doi: 10.1093/nar/gkv1117
Vincent Hervé, Thomas Junier, Saskia Bindschedler, Eric Verrecchia, Pilar Junier Diversity and ecology of oxalotrophic bacteria. World journal of microbiology & biotechnology, 32 (2016) doi: 10.1007/s11274-015-1982-3
Boutet E, Lieberherr D, Tognolli M, Schneider M, Bansal P, Bridge AJ, Poux S, Bougueleret L, Xenarios I. UniProtKB/Swiss-Prot, the Manually Annotated Section of the UniProt KnowledgeBase: How to Use the Entry View. Methods Mol Biol. , 1374:23-54 (2016) doi: 10.1007/978-1-4939-3167-5_2