What we do

In the Computational Structural Biology (CSB) Group, we focus on the development of methods and algorithms to model, simulate and analyse three-dimensional protein structures and their molecular properties in order to apply these techniques to the understanding of biological processes at a molecular level. Our main emphasis is on homology modelling – using evolutionary information to model protein tertiary and quaternary structures. Applications in biomedical research include the study of protein-ligand interactions, drug discovery, structure-guided protein engineering, and the interpretation of mutations related to diseases and drug resistance. The group develops the SWISS-MODEL tool.

Find out about the Group’s activities

Main publications 2021

  • Studer G et al.
    ProMod3—A versatile homology modelling toolbox
    PLoS Computational Biology, 10.1371/journal.pcbi.1008667
  • Robin X et al.
    Continuous Automated Model Evaluation (CAMEO)—Perspectives on the future of fully automated evaluation of structure prediction methods
    Proteins: Structure, Function, and Bioinformatics, 10.1002/prot.26213
  • Pereira J & Schwede T
    Interactomes in the era of deep learning
    Science, 10.1126/science.abm8295