What we do

In the Evolutionary Systems Biology Group, we study the evolution and evolvability of biological systems at all levels of biological organization, from genes and genomes to biological networks and whole organisms. We develop bioinformatics tools to integrate data from a variety of sources, including comparative whole-genome sequence data, microarray expression data, and high-throughput protein interaction data. Our work uses comparative analysis of genomic data, laboratory evolution experiments and mathematical modelling.

Find out about the Group’s activities

Main publications 2021

  • van Gestel J & Wagner A
    Cryptic surface-associated multicellularity emerges through cell adhesion and its regulation
    PLoS Biology, 10.1371/journal.pbio.3001250
  • Karve S and Wagner A
    Multiple Novel Traits without Immediate Benefits Originate in Bacteria Evolving on Single Antibiotics
    Molecular Biology and Evolution, 10.1093/molbev/msab341
  • Dasmeh P and Wagner A
    Yeast Proteins may Reversibly Aggregate like Amphiphilic Molecules
    Journal of Molecular Biology, 10.1016/j.jmb.2021.167352


University zurich

Andreas Wagner
Evolutionary Systems Biology Group
University of Zurich
Group Webpage

Domain(s) of activity:

  • Evolution and phylogeny
  • Comparative genomics
  • Deep sequencing data
  • Evolutionary biology
  • Experimental biology
  • Functional genomics
  • Population genetics

Domain(s) of application:

  • Basic research