Tag: systems biology

What we do Discovering how genetic variation leads to changes in traits underlies the study of human disease and the understanding of the evolutionary process. What makes each human individual different and the diversity of life on earth are, to...

Focus on the group's mission The Swiss-Prot team excels in the art of generating machine-readable knowledge of biology from the ever growing body of scientific publications. It is harnessing the power of deep learning to accelerate literature...

What we do Tumors are molecularly diverse and each tumor is an evolutionary system on its own. The inter- and intra-tumor heterogeneity influence the clinical and biological behavior of cancers and has important implications in tumor progression,...

Focus on the group's mission The Vital-IT team provides bioinformatics collaborative support to life science projects in Switzerland and abroad through collaborations with academic and industry partners. Thanks to its diverse expertise in...

Data management We organize, clean & control the quality of your datasets for subsequent analysis. In addition, we can process, transform and align your datasets to existing standards and make them available as a database. We can propose...

Are you working with multi-omics and aiming to make the generated data shareable and reusable? Find out what it entails and some of the tools that may help.

What we do The Snijder Lab is pioneering multiplexed image-based drug screening in patient biopsies, a technique we call pharmacoscopy, for both systems biology and personalized medicine. In an intervention trial, pharmacoscopy-guided treatments...

What we do The Computational Genetics and Epigenetics of Cancer Group aims to assess contribution of chromatin changes to cancer initiation and progression and associate them with genetic modifications. To achieve this goal, we employ advanced...

What we do Our group’s overall research focuses in the emerging field of artificial intelligence applied to health. Health data is generated from a variety of sources and comprises molecular profiles, medical records, digital biomarkers and social...

The frilled dragon exhibits a distinctive large erectile ruff. This lizard usually keeps the frill folded back against its body but can spread it as a spectacular display to scare off predators. A multidisciplinary team led by SIB Group Leader...

An ERC Advanced Grant has been awarded to SIB Group Leader Michel Milinkovitch for his research project entitled "Identifying how Evolution exploits physical properties of tissues to generate the complexity and diversity of Life (EVOMORPHYS)”.

Are you a bioinformatician with a remarkable early career, a graduate student who published an outstanding paper or did you develop a bioinformatics resource with an important impact on the life science community? SIB is supporting bioinformatics...

In 2019, the SIB Bioinformatics Awards will be presented for the 10th time, providing a great occasion to reach out to past laureates and ask them where they are now in their career. In this interview, we met with Christoph Zechner,...

In 2019, the SIB Bioinformatics Awards will be presented for the 10th time, providing a great occasion to reach out to past laureates and ask them where they are now in their career. In this interview, we met with Jakob Ruess, co-recipient of...

In 2019, the SIB Bioinformatics Awards will be presented for the 10th time, providing a great occasion to reach out to past laureates and ask them where they are now in their career. In this interview, we met with Rajesh Ramaswamy, recipient of the...

An intricate network of minuscule crevices adorns the skin surface of the African bush elephant. By retaining water and mud, these micrometer-wide channels greatly help elephants in regulating their body temperature and protecting their skin...

What we do We are interested in studying ecological and evolutionary factors that determine the structure, function and diversity of microbial communities – with a focus on the ocean ecosystem and the gastrointestinal tract of animals and humans....

Discover the spirit behind Switzerland’s vibrant community of scientists dedicated to making sense out of biological data...

Hundreds of SIB Members from across Switzerland came to Biel/Bienne on 26 June to attend the SIB Days – our 2-day internal conference and a unique opportunity for the bioinformatics community to connect.

What we do We develop and apply computational and – most recently – experimental methods to analyse and design complex cellular networks, with a focus on large-scale mechanistic approaches. The group comprises biologists, computer scientists,...

What we do The main research interest of the Genome Systems Biology (GSB) Group is the structure, function, and evolution of the genome-wide regulatory networks that cells use to control their gene expression state. Typical questions that we are...

What we do We study gene regulation through the analysis and modelling of genome-wide datasets. We collaborate closely with experimental researchers on various biological topics, including cancer progression, chromatin biology and cellular...

What we do In the Science IT (S3IT) unit, we provide support for science in general, and for life science and medicine in particular. S3IT serves as a partner for both local and national projects to enable competitive research with the advanced...

What we do With the advent of high-throughput technologies and clinical information systems, the life sciences and clinical sciences now produce very large amounts of data (big data). Our goal at CI4CB is to uncover hidden patterns in these data,...

What we do Our research interests in the Scientific Computing Group lie in the area of multiscale/multiphysics modelling and parallel large-scale simulations of biological systems. We focus on the development of new computational models and...

What we do We study evolution. Topics include genotype-phenotype maps, adaptive landscapes, mutation bias, and the genetic code. We carry out our research using both modeling and data-driven approaches, as well as via collaboration with...

What we do Mathematical modelling is becoming more and more instrumental in life sciences; the data complexity and the high number of interacting components, from molecules to animals, render intuitive reasoning very difficult. The idea consists...

What we do We combine Evolutionary and Developmental Biology as well as genomic approaches with the study of physical processes to understand the mechanisms generating life’s complexity and diversity. The self-organizational capabilities of...

What we do The Molecular Modelling Group studies molecular interactions using modelling techniques such as homology modelling, molecular dynamics, docking and free energy simulations. Our main activity consists in developing and applying methods...

What we do The Molecular Modelling Group studies molecular interactions using modelling techniques such as homology modelling, molecular dynamics, docking and free energy simulations. Our main activity consists in developing and applying methods...

What we do In the Proteome Informatics Group (PIG), we are involved in software and database development for the benefit of the proteomics and glycomics communities. These resources are made available through the Expasy server. Software tools...

What we do Our group focuses on studying social interactions in microbial communities and how they evolve. We follow an interdisciplinary approach, where we quantify and characterize interactions within small bacterial communities in the lab, and...

What we do Our group is located in the Department of Biomedicine (DBM) at the University of Basel. We collaborate with scientists from DBM on projects covering a broad spectrum of research topics, from cellular differentiation and evolutionary...

What we do The Computational Biology Group (CoBi) develops computational models of developmental processes. We focus on the delineation of fundamental developmental mechanisms and develop data-driven mechanistic 4D in silico models of...

What we do In the Laboratory of Systems Biology and Genetics (LSBG), we use high-throughput sequencing, single cell genomics, microfluidics, and computational approaches: to decipher the regulatory code in Drosophila and mammals with a specific...

What we do In the Scientific and Parallel Computing (SPC) Group, we develop new algorithms and methods to better understand and/or predict various phenomena in biology. We focus on multiscale modelling and computing, high-performance computing,...

What we do The Computational Systems Oncology lab integrates algorithmic design, numerical modelling, and molecular biology approaches to address relevant questions in cancer biology and therapeutics. We explore single and combinations of genetic...

What we do In the Interfaculty Bioinformatics Unit of the University of Bern (IBU), we provide services and expertise to assist researchers of the three “Life-Science” Faculties and Insel hospital in data analysis and project planning for...

What we do We develop concepts and algorithmic tools for the analysis of large-scale biological and clinical data. We participate in many genome-wide association studies (GWAS) for human traits and have a particular interest in the integration of...

With the creation of the SIB Swiss Institute of Bioinformatics in 1998, Switzerland made a historical move and positioned itself as a pioneer in the field of data science.

The mammalian brain is characterised by the development of a vast neocortex that is superposed to the ancien ‘reptilian’ paleocortex. This distinction derives from how neurones are made. But how different parts of the brain decide which...

What we do The individual cells of a body exhibit a stunning diversity of phenotypes, despite carrying a largely identical genetic makeup. This is due to the distinct ways in which the same genetic information can be read, interpreted and...

Whether we are retracing the history of our ancestors, designing new drugs or understanding what gives Swiss Gruyère its unique flavour, bioinformatics has become an essential discipline.

The new edition of the SIB Profile celebrates the 20 years of the Institute (1998-2018).

Each year, the journal Nature issues about 300 "News & Views" articles, which summarize and scrutinize a particularly important piece of research published in the journal. For its 'Best of 2017' selection, Nature's editors picked out seven News...

Last week, the 13th edition of the Basel Computational Biology Conference, co-organized by SIB Swiss Institute of Bioinformatics and the Biozentrum University of Basel, gathered over 500 participants from all over the globe. Among them,...

The last year has been full of developments for SIB, from biocuration, with SIB hosting the 9th International Biocuration Conference, to several projects in personalized health and many more scientific advances...

From the clown fish to leopards, skin colour patterns in animals arise from microscopic interactions among coloured cells that obey equations discovered by the mathematician Alan Turing. Today, researchers at the University of Geneva (UNIGE),...