Tag: structural biology

Discover a method to automatically generates queries and democratize glycoinformatics.

What we do The multidisciplinary research activities of the group combine molecular simulations, structural bioinformatics, machine learning and experimental validation. The group contributed to the development of algorithms for overcoming the...

What we do We aim to understand how proteins translate recognition of endogenous biomolecules (or pharmaceutical drugs) into tightly regulated patterns of cellular signaling. We use techniques such as atomistic structural modeling and simulations...

If you are working in computer-aided drug design, this in silico talk is for you: SIB Senior Research Scientist Ute Röhrig takes you on a journey to push the boundaries of knowledge around IDO1 and its role in immunotherapy resistance.

Cellestia Biotech is initiating a new drug discovery program focused on TFs. The programme, which addresses unmet medical needs in cancer, autoimmune and inflammatory disorders (AIIDs), is launched in collaboration with Vincent Zoete

Addex Therapeutics and SIB have been awarded a CHF600K Innosuisse grant to apply computational approaches developed by SIB to identify new therapeutic indications for a potent and selective dopamine D1 receptor antagonist.

Focus on the group's mission The Vital-IT team provides bioinformatics collaborative support to life science projects in Switzerland and abroad through collaborations with academic and industry partners. Thanks to its diverse expertise in...

Data management We organize, clean & control the quality of your datasets for subsequent analysis. In addition, we can process, transform and align your datasets to existing standards and make them available as a database. We can propose...

Scientists at SIB and the University of Basel, and Chelonia Applied Sciences (Basel), are part of a European effort to find molecules active against COVID-19 - and to accelerate this process in the future.

From where did the new coronavirus (nCoV, see box) arise, and how did it move to humans? How is it spreading and evolving? How can we develop therapies to treat it? SIB Groups provide a range of tools and resources that can help researchers answer...

The PrecisionMed.ch website, developed by the SIB Swiss Institute of Bioinformatics, in collaboration with the University of Lausanne and the CHUV (Lausanne University Hospital), with the support of the SantéPerSo initiative, offers illustrated...

Are you a bioinformatician with a remarkable early career, a graduate student who published an outstanding paper or did you develop a bioinformatics resource with an important impact on the life science community? SIB is supporting bioinformatics...

On 16 December 2018, the count of total jobs run on the SIB Resource SwissDrugDesign passed the symbolic one-million mark.

Take a closer look at an SIB Resource dedicated to making protein modelling accessible to life scientists from around the world: on the occasion of its 25th anniversary, we put a few questions to the SWISS-MODEL development team...

This week, several deep learning methods have led to remarkable advances at the global event for the evaluation of protein structure prediction methods: the 13th CASP experiment. Torsten Schwede and Matteo Dal Peraro, two SIB Group Leaders involved...

Bioinformatics is fundamental to precision medicine. But why? How do hospitals and researchers benefit from bioinformatics to help patients? Canal9 TV Channel, the Oncology department of UNIL/CHUV and SIB all set out together to find answers to...

What we do The overall objective of our research is to understand the role that structure and dynamics play in the definition of the function of biomolecules. In order to perform their function, proteins and other biological molecules undergo a...

Discover the spirit behind Switzerland’s vibrant community of scientists dedicated to making sense out of biological data...

Hundreds of SIB Members from across Switzerland came to Biel/Bienne on 26 June to attend the SIB Days – our 2-day internal conference and a unique opportunity for the bioinformatics community to connect.

Why do DNA loops forming different knot types sediment at different speeds? Researchers from SIB, UNIL and EPFL joined forces with Polish colleagues to answer this question.

What we do The laboratory specializes in the development of computer-aided algorithms, programs and databases for protein engineering, drug design and structure-based immunoinformatics with applications in oncology, notably in immunotherapy of...

What we do In the Computational Structural Biology (CSB) Group, we focus on the development of methods and algorithms to model, simulate and analyse three-dimensional protein structures and their molecular properties in order to apply these...

What we do The Molecular Modelling Group studies molecular interactions using modelling techniques such as homology modelling, molecular dynamics, docking and free energy simulations. Our main activity consists in developing and applying methods...

What we do The Molecular Modelling Group studies molecular interactions using modelling techniques such as homology modelling, molecular dynamics, docking and free energy simulations. Our main activity consists in developing and applying methods...

What we do In the Proteome Informatics Group (PIG), we are involved in software and database development for the benefit of the proteomics and glycomics communities. These resources are made available through the Expasy server. Software tools...

What we do The Laboratory of Protein Design & Immunoengineering started in March 2015. We have established both the computational and experimental branches of our research.We currently perform our computational calculations at the High...

What we do Our main goal at the Laboratory for Biomolecular Modeling is to understand the physical and chemical properties of complex biological systems, in particular their function with regard to structure and dynamics. To this end, we use and...

Khipu – or knotted strings – were used by several Andean cultures to record information. Similarly, knots in DNA can reveal a lot about the molecule’s 3D organisation...

With the creation of the SIB Swiss Institute of Bioinformatics in 1998, Switzerland made a historical move and positioned itself as a pioneer in the field of data science.

Whether we are retracing the history of our ancestors, designing new drugs or understanding what gives Swiss Gruyère its unique flavour, bioinformatics has become an essential discipline.

The new edition of the SIB Profile celebrates the 20 years of the Institute (1998-2018).

As it squeezes down the chromatin fibre, the cohesin protein complex extrudes a growing loop of DNA - a bit like the quick-lacing system of trail-running shoes. But what is powering the movement of the protein?

Last week, the 13th edition of the Basel Computational Biology Conference, co-organized by SIB Swiss Institute of Bioinformatics and the Biozentrum University of Basel, gathered over 500 participants from all over the globe. Among them,...

Some proteins form a specific knot when they fold into their native structures. The function of knots in proteins and the mechanism of their formation are still poorly understood. In order to study protein knots, it is necessary to identify knotted...

The last year has been full of developments for SIB, from biocuration, with SIB hosting the 9th International Biocuration Conference, to several projects in personalized health and many more scientific advances...

When it comes to packaging large amounts of information into tiny volumes, biology and physics often buddy up to reach creative solutions. The problem is even more complex with DNA, as the compacted information must also remain accessible to the...

Today in the national news, Marie-Claude Blatter (Responsible - SIB Outreach activities) and Vincent Zoete (Associate director - Molecular Modelling group) presented SIB's role in drug design and bioinformatics outreach on the Radio Télévision...

Identifying and supporting SIB Resources Every four years, the Institute’s External Scientific Advisory Board (SAB) provides recommendations on the portfolio of SIB-supported Resources. By taking into account competitive criteria – such as the...