Tag: proteins and proteomes

Discover a method to automatically generates queries and democratize glycoinformatics.

Acceleration of biomarker identification to improve clinical diagnostics.

Focus on the group's mission The Swiss-Prot team excels in the art of generating machine-readable knowledge of biology from the ever growing body of scientific publications. It is harnessing the power of deep learning to accelerate literature...

Two further resources developed by SIB Groups have been designated as of crucial importance for life sciences, as a result of the latest edition of the selection process led by ELIXIR at the European level: Cellosaurus and Rhea.

A new workshop for classrooms offers the opportunity to discover the SARS-CoV-2 coronavirus, in particular its genome and proteins. These materials result from a partnership between SIB and the University of Lausanne (SCMS).

The Human Proteome Project (HPP) of the Human Proteome Organisation (HUPO) is ten years old. Its mission? To generate the map of the protein-based molecular architecture of the human body.

One particular AMP from the venom of a tropical wasp, Polybia paulista, appears not only to present anti-cancer properties but also to fight off an infection known as Chagas disease which affects millions of people every year and worldwide. Its...

Cryptococcus neoformans is a fungal pathogen which infects cells by using the copper it finds in them for its own metabolism, while the host retaliates by raising the concentration of metal to create a toxic environment for the pathogen. In...

The SIB CALIPHO Group and ENYO Pharma SA worked hand-in-hand in a transnational public-private partnership (PPP) to make human protein interaction data publicly available and FAIR, through the SIB Resource neXtProt.

Read how the ZBP1 protein comes into action when cells are undergoing stress in a viral infection for example, but is also associated with the onset and progression of certain cancers, as well as several autoimmune diseases.

Discover the role tiny entities such as proteins play in the grand scheme of things – from smells to diseases – through an inspired dialogue between a biologist and a non-specialist.

What we do The responsibility of the proteome informatics at the FGCZ is to evaluate and provide services to the mass spectrometry scientists at our center, ranging from sample annotation, data archiving, processing, analysis, visualization up to...

A protein that has been coined HMCES, which is found throughout the three domains of life, and even in certain viruses it seems, can repair damage on single-stranded DNA.

One particular fungus, Armillaria gallica, created a buzz in the 1990s when scientists announced that they had found a colony whose rhizomorphs seemingly stretched over tens of acres. However, as rhizomorphs grow, they also spend a lot of time...

For shoots to appear along the length of a rose's stem, besides light, sugars are required in huge quantities and, for this, many enzymes are triggered into action. In the common modern rose, Rosa hybrida, one such enzyme is a vacuolar invertase -...

Viruses need to get inside cells in order to multiply, and this is what brings on infection. Viruses recognise molecules on the surface of cells to which they bind, thus enabling them - or parts of them - to enter the host cells where they rapidly...

When too much uric acid is produced, it precipitates as urate crystals that slowly build up finally causing excruciating pain - surprisingly at the base of the big toe in about half of gout cases. Why is uric acid elimination sometimes...

What we do The Clinical Proteotype Analysis Center in Zurich is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of disease/wellness, through the development and application of robust, quantitative,...

What we do The Clinical Proteotype Analysis Center in Zurich is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of disease/wellness, through the development and application of robust, quantitative,...

Toxic compounds that find their way into microorganisms are usually funnelled out by what are known as efflux pumps. These pumps pose one problem for humans however, and that is drug resistance. One such pump is the Trichophyton rubrum ABC...

One promising attempt to shift A, B and AB blood types to the 'universal' O blood type involves bacteria from our gut microbiome, and two enzymes: a D-galactosamine deacetylase and a D-galactosamine galactosaminidase.

Understanding how pain occurs on the molecular plane helps scientists find ways of designing pain relievers. However, more often than not, pain is usually accompanied by swelling which has a protective role. So we face a conundrum: how do you...

A plant pathogen known as Phytophthora sojae uses a lure to confound soybean's immune response to infection.

Magnetotactic bacteria have learned to use the Earth's magnetic field as a speedy highway to travel to nutrients of interest. They do this by way of minute iron-rich pouches - or magnetosomes - that are aligned along their middle and act much like...

Because of their inability to move, plants have devised the most elaborate ways of deceiving their environment in order to grow. European maize, for example, is able to synthesize a molecule known as (E)-β-caryophyllene which is released by...

SIB Group Leader Frédérique Lisacek, glycoinformatician, and Philippe Le Mercier, molecular virologist, present a dynamic view of their recent joint paper on this topic and provide a tour d’horizon of the tools developed at SIB that can be used to...

In cells, special enzymes - of which there are many - have the task of adding or removing molecules onto or from proteins to this end. One of these is SET domain protein 3, or SETD3 which shifts the behaviour of a certain kind of actin...

Life strives on reproduction. Over time, it has found very imaginative ways to proliferate in multitudinous forms - from protozoa wriggling in the bottom of pools to big cats racing across the African plains and birds flying swiftly through the...

Would Nature not tend instinctively towards symmetry? In our eyes, symmetry often spells equilibrium, a source of beauty. Consider the work of architects, or engineers. Houses, skyscrapers, bridges and dams are usually symmetric which is not only,...

Are you a bioinformatician with a remarkable early career, a graduate student who published an outstanding paper or did you develop a bioinformatics resource with an important impact on the life science community? SIB is supporting bioinformatics...

We are all bound to become prey, predator or competitor one day. Whichever way you look at it. That is why, over time, all living beings have acquired their very own palette of defence mechanisms. Roses grow thorns. Bacteria fire toxins...

In 2019, the SIB Bioinformatics Awards will be presented for the 10th time, providing a great occasion to reach out to past laureates and ask them where they are now in their career. In this interview, we met with Hannes Röst, recipient of the...

There are many proteins crouching in the recesses of databanks whose role in vivo eludes researchers. Despite similarities of all kinds they may share with other proteins, they seem to have been designed for another purpose...

In 2019, the SIB Bioinformatics Awards will be presented for the 10th time, providing a great occasion to reach out to past laureates and ask them where they are now in their career. In this interview, we met with Lukas Burger, recipient of the...

Though it may seem a paradox, life is riddled with barriers. This is because it is sometimes necessary to create dead ends to keep things at a healthy distance. Obstructions of this kind exist at all levels of living matter...

No one likes the cold. Humans wear scarves, fur boots, quilted coats and woollen hats to keep the harshness of winter out while other creatures grow their own fur or line their bodies with a thick layer of blubber...

Integrating biological and chemical knowledge for a more complete understanding of biological systems – and better links between SIB and ELIXIR Core Data Resources.

This week, several deep learning methods have led to remarkable advances at the global event for the evaluation of protein structure prediction methods: the 13th CASP experiment. Torsten Schwede and Matteo Dal Peraro, two SIB Group Leaders involved...

Movement is what sustains life. Organisms need to move to find food, seek shelter and to reproduce. Mobility is also essential inside organisms where cells are continuously dividing and migrating. There is also unceasing movement inside every cell...

Discover the spirit behind Switzerland’s vibrant community of scientists dedicated to making sense out of biological data...

Hundreds of SIB Members from across Switzerland came to Biel/Bienne on 26 June to attend the SIB Days – our 2-day internal conference and a unique opportunity for the bioinformatics community to connect.

Left only to the passage of time, everything gravitates towards chaos. Gardens become overgrown. Roads gather potholes and cracks. Relationships wither, and teeth rot. We have ways of dealing with this however.

What we do We focus on the bioinformatic analysis and integration of state-of-the-art functional genomics data that we obtain through close collaboration with experimental biologists (genome sequences, gene and protein expression, metabolomics,...

What we do In the Bioinformatics / Systems Biology Group, we study the dynamics of entire biological systems, both at evolutionary time-scales and at shorter time-scales – down to a few minutes. We often work in close collaboration with laboratory...

What we do In the Proteome Informatics Group (PIG), we are involved in software and database development for the benefit of the proteomics and glycomics communities. These resources are made available through the Expasy server. Software tools...

What we do In the Computational Cancer Biology Group, our aim is to study interactions between cancer and immune cells. We are focusing on molecular and cellular aspects of cancer immune cell interactions. At the molecular level, we have developed...

Are researchers austere? Is bioinformatics arid? Judge for yourself, with this handsome book published by SIB to mark the Institute's 20th anniversary, thanks to the financial support of many sponsors.

Life is a continuous balance between what needs to remain, and what must disappear. We are not aware of it but our bodies unceasingly shed cells that have received orders to die, which is a necessary process if tissues are to be renewed or to stay...

What we do We aim to use a combination of bioinformatics and experimental methodologies to increase knowledge about the function of the 20,000 protein-coding genes in the human genome. Our main mission is the development of neXtProt, a human...

With the creation of the SIB Swiss Institute of Bioinformatics in 1998, Switzerland made a historical move and positioned itself as a pioneer in the field of data science.