Tag: genes and genomes

From education to blood pressure, partners in couples often tend to present striking trait similarities. For the first time, the reasons for this are teased apart by SIB’s Zoltán Kutalik and his team.

Biodiversity Genomics Europe: Characterizing and preserving life using DNA data

Bringing artificial intelligence and bioinformatics closer in Switzerland, Idiap and SIB signed a collaboration agreement. By becoming a partner institution of SIB, Idiap ensures its groups active in bioinformatics benefit from its national network...

The protein responsible for the fusion between egg and sperm may have appeared long before the organisms that rely on it for their sexual reproduction (e.g., plants and animals).

What we do The Genomics and Health Informatics (GHI) group aims to leverage the power of combined high-content sequencing, cellular imaging, and clinical data to address biological questions related to human disorders. Such questions include how...

While most of the human genome is the same across individuals, genomic mishaps such as deletions and duplications can reduce or increase the number of copies of specific genetic fragments. These mishaps are also known as copy-number variations or...

The first evidence of the consequences of parthenogenesis – a type of asexual reproduction – on genome evolution is reported in an international study co-led by scientists at UNIL and SIB.

Animals as different as wasps and snakes have adopted surprisingly similar molecular mechanisms to squirt toxins out of their specialized cells. This is revealed by a study led by SIB scientists, who have conducted the first comparative analysis of...

As members of the Swiss node of the European Reference Genome Atlas initiative, several SIB Groups are participating in a Pilot Project to sequence reference genomes for selected species across Europe. The results of the first phase of the Pilot...

From SARS-CoV-2 monitoring to HIV antiviral drug resistance detection, the SIB Resource V-pipe orchestrates several software packages to detect the genomic diversity of a virus population in a sample or individual. 

Thousands of genetic markers have already been robustly associated with complex human traits, such as Alzheimer’s disease, cancer, obesity, or height. A new statistical method, developed by Olivier Delaneau’s group at the SIB, offers game-changing...

[BC]2 is Switzerland's main event in the domain of Computational Biology, and one of the major events of its kind in Europe. The 2021 edition “Harnessing biological data: from molecular processes to human health” will be held on 13 – 15 September,...

A new version of ChromosomeWalk offers a gateway to an entertaining ‘genome browser’, enriched with a new selection of stories on fascinating genes – in English, French and German – as well to the PrecisionMed website for an illustrated tour of...

A changing planet threatens many species, including bumblebees - globally important pollinators in natural ecosystems and in agricultural food production. An international team co-led by SIB researchers at the University of Lausanne sequenced the...

A benchmarking study of models predicting the location and sequence of transcription factor binding sites has been undertaken by an international team led by researchers at SIB, EPFL and the Russian Academy of Sciences.

Are you working with multi-omics and aiming to make the generated data shareable and reusable? Find out what it entails and some of the tools that may help.

A new open-source method allows to accurately estimate how much of our genome makes us susceptible to environmental risk factors, which in turn predispose us to certain pathologies. The study describing the method, led by the SIB Group of Zoltán...

From where did the new coronavirus (nCoV, see box) arise, and how did it move to humans? How is it spreading and evolving? How can we develop therapies to treat it? SIB Groups provide a range of tools and resources that can help researchers answer...

An international team of scientists report in the journal Genome Biology results from a pilot project, co-led by SIB Group Leader Robert Waterhouse at the University of Lausanne, to kick-start the global sequencing initiative of thousands of...

SIB Scientists demonstrate how genome-comparison-based evolutionary approaches can be used to improve draft assemblies.

Researchers from UNIL, UNIGE and SIB provide the researchers’ community with an extremely powerful computer tool to facilitate the interpretation of the genome’s Big Data

Uncover known – as well as yet uncharacterized - Toxin-Antitoxin Systems in your bacterial genomes, with this discovery pipeline and database

A new tool and web-platform bringing together leading orthology SIB resources to take the pain out of your evolutionary inference or functional annotation analyses

A behind-the-scenes look at a recent paper on the origin of beetle biodiversity, and the bioinformatics tools used along the way.

What we do Our group is interested in the regulatory machinery controlling gene expression. We investigate it by analyzing population scale multi-omics data sets (e.g. genomics, transcriptomics, epigenomics, proteomics) in which we use genetic...

Eleonora Porcu from the SIB Group of Zoltán Kutalik at the University of Lausanne proposes a Transcriptome-Wide Mendelian Randomization method (TWMR) which, applied to 43 complex traits, uncovers hundreds of previously unreported gene-trait...

Two 31,000-year-old milk teeth from an excavation site in northeastern Siberia have led to the discovery of a previously unknown population that lived in the area during the last ice age.

SIB Group Leader Niko Beerenwinkel at ETH Zurich introduces V-Pipe, a new end-to-end pipeline tool to mine viral genomes and improve clinical diagnostics.

Just a few days after the IPBES’ global biodiversity assessment was presented in Paris, SIB Scientists at the University of Lausanne published a paper explaining the origin of the biodiversity observed among beetles, arguably the largest species...

In 2019, the SIB Bioinformatics Awards will be presented for the 10th time, providing a great occasion to reach out to past laureates and ask them where they are now in their career. In this interview, we met with Shijulal Nelson-Sathi,...

Are you a bioinformatician with a remarkable early career, a graduate student who published an outstanding paper or did you develop a bioinformatics resource with an important impact on the life science community? SIB is supporting bioinformatics...

In 2019, the SIB Bioinformatics Awards will be presented for the 10th time, providing a great occasion to reach out to past laureates and ask them where they are now in their career. In this interview, we met with Inanc Birol, recipient of the...

In 2019, the SIB Bioinformatics Awards will be presented for the 10th time, providing a great occasion to reach out to past laureates and ask them where they are now in their career. In this interview, we met with Joshua Payne, recipient of...

In 2019, the SIB Bioinformatics Awards will be presented for the 10th time, providing a great occasion to reach out to past laureates and ask them where they are now in their career. In this interview, we met with Charles E. Vejnar, co-recipient of...

In 2019, the SIB Bioinformatics Awards will be presented for the 10th time, providing a great occasion to reach out to past laureates and ask them where they are now in their career. In this interview, we met with Slavica Dimitrieva,...

In 2019, the SIB Bioinformatics Awards will be presented for the 10th time, providing a great occasion to reach out to past laureates and ask them where they are now in their career. In this interview, we met with Anamaria Necsulea, recipient...

In 2019, the SIB Bioinformatics Awards will be presented for the 10th time, providing a great occasion to reach out to past laureates and ask them where they are now in their career. In this interview, we met with Christophe Dessimoz, recipient of...

In 2019, the SIB Bioinformatics Awards will be presented for the 10th time, providing a great occasion to reach out to past laureates and ask them where they are now in their career. In this interview, we met with Guillaume Rey, recipient of the...

In 2019, the SIB Bioinformatics Awards will be presented for the 10th time, providing a great occasion to reach out to past laureates and ask them where they are now in their career. In this interview, we met with Nacho Molina, recipient of the...

A study led by the EPFL team of Elisa Oricchio and the SIB team of Giovanni Ciriello (University of Lausanne) shows how a mutated gene can affect the three-dimensional interactions of genes in the cell, leading to various forms of cancer.

In 2019, the SIB Bioinformatics Awards will be presented for the 10th time, providing a great occasion to reach out to past laureates and ask them where they are now in their career. In this interview, we met with Lukas Burger, recipient of the...

In 2019, the SIB Bioinformatics Awards will be presented for the 10th time, providing a great occasion to reach out to past laureates and ask them where they are now in their career. In this interview, we met with Julien Roux, recipient of the 2009...

Every minute, each one of our trillions of cells carries out countless chemical reactions to convert food into energy, build proteins and eliminate toxic waste for instance. Taken as a whole, all these reactions make up our metabolism. But by which...

What makes the wheat stem sawfly such a major pest in the grasslands of North America? An international study co-led by SIB researchers at the University of Lausanne unravels its genome...

References form the basis of our comprehension of the world: they enable us to measure the height of our children or the efficiency of a drug. But when such yardsticks are faulty, doubts are cast on all the measurements that derive from them.

Bacterial genomes are a treasure trove of information, be it for the development of novel antibiotics or the protection of crops against pathogens. A study, led by the group of SIB’s Christian Ahrens at Agroscope, shows that unravelling those...

What we do We are interested in studying ecological and evolutionary factors that determine the structure, function and diversity of microbial communities – with a focus on the ocean ecosystem and the gastrointestinal tract of animals and humans....

Predicting diseases, one step aheadOur health depends not only on the genes that Nature dealt us at birth, but also on the environment we evolve in and the kind of life we lead.