Tag: gene regulation

The first evidence of the consequences of parthenogenesis – a type of asexual reproduction – on genome evolution is reported in an international study co-led by scientists at UNIL and SIB.

Animals as different as wasps and snakes have adopted surprisingly similar molecular mechanisms to squirt toxins out of their specialized cells. This is revealed by a study led by SIB scientists, who have conducted the first comparative analysis of...

Do you usually wake up feeling rested but not hungry? It may be the sign of a particularly large meal the evening before – or simply reflect the difference in circadian rhythm between your gut and brain.

The SIB Resource Bgee is a database for retrieval and comparison of gene expression patterns across multiple animal species. It provides an intuitive answer to the question “where is a gene expressed?” and supports research in cancer and...

With only 1% difference, the human and chimpanzee protein-coding genomes are remarkably similar. Understanding the biological features that make us human is part of a fascinating debated line of research.

A benchmarking study of models predicting the location and sequence of transcription factor binding sites has been undertaken by an international team led by researchers at SIB, EPFL and the Russian Academy of Sciences.

What we do The Computational Genetics and Epigenetics of Cancer Group aims to assess contribution of chromatin changes to cancer initiation and progression and associate them with genetic modifications. To achieve this goal, we employ advanced...

What we do Our group is interested in the regulatory machinery controlling gene expression. We investigate it by analyzing population scale multi-omics data sets (e.g. genomics, transcriptomics, epigenomics, proteomics) in which we use genetic...

Eleonora Porcu from the SIB Group of Zoltán Kutalik at the University of Lausanne proposes a Transcriptome-Wide Mendelian Randomization method (TWMR) which, applied to 43 complex traits, uncovers hundreds of previously unreported gene-trait...

In 2019, the SIB Bioinformatics Awards will be presented for the 10th time, providing a great occasion to reach out to past laureates and ask them where they are now in their career. In this interview, we met with José Aguilar-Rodríguez,...

In 2019, the SIB Bioinformatics Awards will be presented for the 10th time, providing a great occasion to reach out to past laureates and ask them where they are now in their career. In this interview, we met with Charles E. Vejnar, co-recipient of...

In 2019, the SIB Bioinformatics Awards will be presented for the 10th time, providing a great occasion to reach out to past laureates and ask them where they are now in their career. In this interview, we met with Christoph Zechner,...

In 2019, the SIB Bioinformatics Awards will be presented for the 10th time, providing a great occasion to reach out to past laureates and ask them where they are now in their career. In this interview, we met with Guillaume Rey, recipient of the...

In 2019, the SIB Bioinformatics Awards will be presented for the 10th time, providing a great occasion to reach out to past laureates and ask them where they are now in their career. In this interview, we met with Nacho Molina, recipient of the...

A study led by the EPFL team of Elisa Oricchio and the SIB team of Giovanni Ciriello (University of Lausanne) shows how a mutated gene can affect the three-dimensional interactions of genes in the cell, leading to various forms of cancer.

The hills and valleys of evolutionDuring the course of the 20th Century, the American population geneticist Sewall Wright was the first to depict evolution as landscapes...

What we do The main research interest of the Genome Systems Biology (GSB) Group is the structure, function, and evolution of the genome-wide regulatory networks that cells use to control their gene expression state. Typical questions that we are...

What we do In the Evolutionary Bioinformatics Group, we are interested in animal genome evolution with a focus on questions arising from evolutionary developmental biology (Evo-Devo). For this, we develop methods and databases to extract reliable...

What we do We study gene regulation through the analysis and modelling of genome-wide datasets. We collaborate closely with experimental researchers on various biological topics, including cancer progression, chromatin biology and cellular...

What we do We study evolution. Topics include genotype-phenotype maps, adaptive landscapes, mutation bias, and the genetic code. We carry out our research using both modeling and data-driven approaches, as well as via collaboration with...

What we do In the Laboratory of Systems Biology and Genetics (LSBG), we use high-throughput sequencing, single cell genomics, microfluidics, and computational approaches: to decipher the regulatory code in Drosophila and mammals with a specific...

Our focus In the Computational Cancer Genomics Group, we are interested in gene regulation in both healthy and diseased cells. Breakthroughs in genomics technologies have led to the production of large volumes of data that could potentially tell...

What we do In the Molecular Allergology group we are aiming to unravel the molecular basis of allergic diseases, antigen presentation, immunotherapies, immunotolerance and tolerance breakage with a combination of functional genomics techniques,...

Identifying and supporting SIB Resources Every four years, the Institute’s External Scientific Advisory Board (SAB) provides recommendations on the portfolio of SIB-supported Resources. By taking into account competitive criteria – such as the...